U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Octbeta1R Octopamine beta1 receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42652, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Octbeta1Rprovided by FlyBase
Official Full Name
Octopamine beta1 receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0038980
Locus tag
Dmel_CG6919
See related
AllianceGenome:FB:FBgn0038980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.67; anon-WO0170980.68; CG6919; DmCG6919; Dmel\CG6919; Dmoa2; DmOctbeta1R; DmOctBeta1R; oa2; Oa2; OA2; OctBeta1; octbeta1r; octbeta1R
Summary
Enables octopamine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of synaptic assembly at neuromuscular junction. Located in plasma membrane. Is expressed in several structures, including antennal lobe commissural pioneer interneuron; brain; epithelial tube; octopaminergic neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4) and ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Octbeta1R in Genome Data Viewer
Location:
94B1-94B2; 3-75 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22497215..22520078)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18322937..18345800)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene testis-enriched HMG-box-containing protein 1 Neighboring gene testis-enriched HMG-box-containing protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Visual Input into the Drosophila melanogaster Mushroom Body. Li J, et al. Cell Rep, 2020 Sep 15. PMID 32937130, Free PMC Article
  2. Transiently increasing cAMP levels selectively in hippocampal excitatory neurons during sleep deprivation prevents memory deficits caused by sleep loss. Havekes R, et al. J Neurosci, 2014 Nov 19. PMID 25411499, Free PMC Article
  3. The neurobiology and evolution of cannabinoid signalling. Elphick MR, et al. Philos Trans R Soc Lond B Biol Sci, 2001 Mar 29. PMID 11316486, Free PMC Article
  4. Starvation-Induced Depotentiation of Bitter Taste in Drosophila. LeDue EE, et al. Curr Biol, 2016 Nov 7. PMID 27720624
  5. A family of octopamine [corrected] receptors that specifically induce cyclic AMP production or Ca2+ release in Drosophila melanogaster. Balfanz S, et al. J Neurochem, 2005 Apr. PMID 15816867

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Concerted Actions of Octopamine and Dopamine Receptors Drive Olfactory Learning.
    Title: Concerted Actions of Octopamine and Dopamine Receptors Drive Olfactory Learning.
  2. Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations.
    Title: Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables octopamine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables octopamine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
octopamine beta1 receptor
Names
CG6919-PA
CG6919-PB
CG6919-PC
CG6919-PE
Octbeta1R-PA
Octbeta1R-PB
Octbeta1R-PC
Octbeta1R-PE
octopamine receptor
octopamine receptor 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22497215..22520078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275914.1 → NP_001262843.1  octopamine beta1 receptor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KHN2, Q2PDQ3, Q4LBC0, Q9VCZ3
    UniProtKB/TrEMBL
    G2J627
    Conserved Domains (2) summary
    pfam00001
    Location:124 → 404
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:112 → 231
    7tm_4; Olfactory receptor

  2. NM_001038975.3 → NP_001034064.1  octopamine beta1 receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G7H820
    Conserved Domains (1) summary
    cd15066
    Location:109 → 415
    7tmA_DmOct-betaAR-like; Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_142800.3 → NP_651057.1  octopamine beta1 receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651057.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KHN2, Q2PDQ3, Q4LBC0, Q9VCZ3
    UniProtKB/TrEMBL
    G2J627
    Related
    FBpp0083653
    Conserved Domains (2) summary
    pfam00001
    Location:124 → 404
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:112 → 231
    7tm_4; Olfactory receptor

  4. NM_001170219.2 → NP_001163690.1  octopamine beta1 receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163690.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIT6, G7H820
    Conserved Domains (2) summary
    pfam00001
    Location:124 → 404
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:112 → 231
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIT6 E1JIT6
Q9VCZ3.1 Q9VCZ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous