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Rad60 Rad60 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42748, updated on 4-Jan-2025

Summary

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Official Symbol
Rad60provided by FlyBase
Official Full Name
Rad60provided by FlyBase
Primary source
FLYBASE:FBgn0039065
Locus tag
Dmel_CG4449
See related
AllianceGenome:FB:FBgn0039065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4449; Dmel\CG4449; drad60; dRad60; RENi
Summary
Involved in double-strand break repair via homologous recombination. Located in nuclear periphery. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Rad60 in Genome Data Viewer
Location:
94E8-94E9; 3-78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23249443..23251477, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19075165..19077199, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene cap-n-collar Neighboring gene fuzzy onions Neighboring gene uncharacterized protein Neighboring gene Elongin A Neighboring gene will decrease acetylation Neighboring gene Peroxin 11c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NetREX-CF integrates incomplete transcription factor data with gene expression to reconstruct gene regulatory networks. Wang Y, et al. Commun Biol, 2022 Nov 23. PMID 36418514, Free PMC Article
  2. And yet, it moves: nuclear and chromatin dynamics of a heterochromatic double-strand break. Caridi PC, et al. Philos Trans R Soc Lond B Biol Sci, 2017 Oct 5. PMID 28847828, Free PMC Article
  3. Nuclear Dynamics of Heterochromatin Repair. Amaral N, et al. Trends Genet, 2017 Feb. PMID 28104289, Free PMC Article
  4. The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity. Vichas A, et al. J Cell Biol, 2015 Dec 7. PMID 26644515, Free PMC Article
  5. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Ryu T, et al. Nat Cell Biol, 2015 Nov. PMID 26502056, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rad60
Names
CG4449-PA
CG4449-PB
CG4449-PC
CG4449-PD
CG4449-PE
CG4449-PF
Rad60-PA
Rad60-PB
Rad60-PC
Rad60-PD
Rad60-PE
Rad60-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23249443..23251477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170227.1 → NP_001163698.1  Rad60, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIU3, E4NKN5
    Conserved Domains (1) summary
    cl00155
    Location:390 → 420
    UBQ; Ubiquitin-like proteins

  2. NM_142877.1 → NP_651134.1  Rad60, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651134.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSB4, Q9VCP1
    UniProtKB/TrEMBL
    E4NKN5, H0RNC3
    Related
    FBpp0083780, FBtr0084388
    Conserved Domains (1) summary
    cl00155
    Location:392 → 422
    UBQ; Ubiquitin-like proteins

  3. NM_001275940.1 → NP_001262869.1  Rad60, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHP8, E4NKN5
    Conserved Domains (1) summary
    cl00155
    Location:389 → 419
    UBQ; Ubiquitin-like proteins

  4. NM_001275937.1 → NP_001262866.1  Rad60, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262866.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIU3, E4NKN5
    Conserved Domains (1) summary
    cl00155
    Location:390 → 420
    UBQ; Ubiquitin-like proteins

  5. NM_001275939.1 → NP_001262868.1  Rad60, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHY5, E4NKN5
    Conserved Domains (1) summary
    cl00155
    Location:391 → 421
    UBQ; Ubiquitin-like proteins

  6. NM_001275938.1 → NP_001262867.1  Rad60, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262867.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSB4, Q9VCP1
    UniProtKB/TrEMBL
    E4NKN5, H0RNC3
    Conserved Domains (1) summary
    cl00155
    Location:392 → 422
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHP8 A0A0B4KHP8
A0A0B4KHY5 A0A0B4KHY5
E1JIU3 E1JIU3
H0RNC3 H0RNC3
Q9VCP1.4 Q9VCP1

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