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Kal1 Kallmann syndrome 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42865, updated on 9-Dec-2024

Summary

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Official Symbol
Kal1provided by FlyBase
Official Full Name
Kallmann syndrome 1provided by FlyBase
Primary source
FLYBASE:FBgn0039155
Locus tag
Dmel_CG6173
See related
AllianceGenome:FB:FBgn0039155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6173; CT19368; Dmel\CG6173; Dmkal; DmKal-1; kal-1; Kal-1
Summary
Predicted to enable peptidase inhibitor activity. Predicted to be involved in neuron differentiation. Located in external side of plasma membrane and extracellular region. Is expressed in several structures, including amnioserosa; border follicle cell; cephalopharyngeal skeleton; embryonic segment; and gut section. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Kal1 in Genome Data Viewer
Location:
95E1-95E5; 3-83 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24141395..24147490)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19967117..19973212)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 10 Neighboring gene Niemann-Pick type C-2f Neighboring gene Seryl-tRNA synthetase-like insect mitochondrial protein Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional dissection of the Drosophila Kallmann's syndrome protein DmKal-1. Andrenacci D, et al. BMC Genet, 2006 Oct 11. PMID 17034626, Free PMC Article
  2. Invertebrate models of kallmann syndrome: molecular pathogenesis and new disease genes. Di Schiavi E, et al. Curr Genomics, 2013 Mar. PMID 23997646, Free PMC Article
  3. Embryonic expression pattern of the Drosophila Kallmann syndrome gene kal-1. Andrenacci D, et al. Gene Expr Patterns, 2004 Nov. PMID 15533820
  4. Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis. Millo H, et al. Mech Dev, 2004 Nov. PMID 15454264
  5. New candidate genes for sex-comb divergence between Drosophila mauritiana and Drosophila simulans. Graze RM, et al. Genetics, 2007 Aug. PMID 17565959, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kallmann syndrome 1
Names
CG6173-PA
Kal1-PA
kal-1
kallmann
kallmann syndrome 1 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24141395..24147490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142963.3 → NP_651220.3  kallmann syndrome 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651220.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTT2, Q8WS92, Q9VCC7
    Related
    FBpp0083934
    Conserved Domains (2) summary
    pfam00041
    Location:177 → 245
    fn3; Fibronectin type III domain
    pfam00095
    Location:96 → 139
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SS0 Q95SS0
Q9VCC7 Q9VCC7

Gene LinkOut

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