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Idh3g Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43102, updated on 4-Jan-2025

Summary

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Official Symbol
Idh3gprovided by FlyBase
Official Full Name
Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gammaprovided by FlyBase
Primary source
FLYBASE:FBgn0039358
Locus tag
Dmel_CG5028
See related
AllianceGenome:FB:FBgn0039358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5028; Dmel\CG5028
Summary
Predicted to enable enzyme activator activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrial matrix. Is expressed in adult head and adult heart. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Idh3g in Genome Data Viewer
Location:
96E9-96E9; 3-88 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25680845..25683780)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21506567..21509502)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L27 Neighboring gene Cardiolipin synthase Neighboring gene Lipophorin receptor 2 Neighboring gene long non-coding RNA:CR46102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development. Zhou J, et al. PLoS Genet, 2019 Sep. PMID 31553718, Free PMC Article
  2. The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila. González Morales N, et al. J Cell Sci, 2023 Jul 1. PMID 37272588, Free PMC Article
  3. Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. Jeong J, et al. PLoS Genet, 2021 Oct. PMID 34714823, Free PMC Article
  4. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. Lim DH, et al. FEBS Lett, 2011 Oct 3. PMID 21889502
  5. Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs. Lim DH, et al. J Cell Biochem, 2013 Feb. PMID 22961661

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in isocitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isocitrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of isocitrate dehydrogenase complex (NAD+) ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
Names
CG5028-PA
CG5028-PB
CG5028-PC
CG5028-PD
Idh3g-PA
Idh3g-PB
Idh3g-PC
Idh3g-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25680845..25683780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104452.2 → NP_001097922.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097922.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MT18, Q9VBN6
    Conserved Domains (1) summary
    TIGR00175
    Location:55 → 386
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

  2. NM_001104453.2 → NP_001097923.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRB8
    Conserved Domains (1) summary
    TIGR00175
    Location:55 → 386
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

  3. NM_143159.3 → NP_651416.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651416.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MT18, Q9VBN6
    Related
    FBpp0084275
    Conserved Domains (1) summary
    TIGR00175
    Location:55 → 386
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

  4. NM_001104454.2 → NP_001097924.1  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097924.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRC1
    Conserved Domains (1) summary
    TIGR00175
    Location:55 → 386
    mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JRB8 A8JRB8
A8JRC1 A8JRC1
Q8MT18 Q8MT18

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