U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tsp96F Tetraspanin 96F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43127, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Tsp96Fprovided by FlyBase
Official Full Name
Tetraspanin 96Fprovided by FlyBase
Primary source
FLYBASE:FBgn0027865
Locus tag
Dmel_CG6120
See related
AllianceGenome:FB:FBgn0027865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD19727; CG6120; Dm.Tsp96F; Dmel\CG6120; LD19727; tsp96F
Summary
Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6 and prostate adenocarcinoma. Orthologous to human CD81 (CD81 molecule); CD9 (CD9 molecule); and TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tsp96F in Genome Data Viewer
Location:
96F5-96F5; 3-89 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25872900..25881427, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21698622..21707149, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Signal peptide peptidase-like Neighboring gene Lnk

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Active Wnt proteins are secreted on exosomes. Gross JC, et al. Nat Cell Biol, 2012 Oct. PMID 22983114
  2. Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model. Linnemannstöns K, et al. J Extracell Vesicles, 2022 Sep. PMID 36103151, Free PMC Article
  3. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
  4. Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium. Linnemannstöns K, et al. Development, 2020 Aug 14. PMID 32611603, Free PMC Article
  5. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tetraspanin 96F
Names
CG6120-PA
CG6120-PB
CG6120-PC
Tetraspanin96F
Tsp96F-PA
Tsp96F-PB
Tsp96F-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25872900..25881427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276048.2 → NP_001262977.1  tetraspanin 96F, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3X2
    Conserved Domains (1) summary
    pfam00335
    Location:10 → 257
    Tetraspannin; Tetraspanin family

  2. NM_079776.3 → NP_524500.1  tetraspanin 96F, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524500.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3X2
    Related
    FBpp0084286
    Conserved Domains (1) summary
    pfam00335
    Location:10 → 257
    Tetraspannin; Tetraspanin family

  3. NM_001276047.2 → NP_001262976.1  tetraspanin 96F, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262976.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH03
    Conserved Domains (2) summary
    cd03155
    Location:107 → 233
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 261
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KH03 A0A0B4KH03
Q9V3X2 Q9V3X2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous