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sat1a.2 spermidine/spermine N1-acetyltransferase 1a, duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 431716, updated on 4-Jan-2025

Summary

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Official Symbol
sat1a.2provided by ZNC
Official Full Name
spermidine/spermine N1-acetyltransferase 1a, duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040704-4
See related
Ensembl:ENSDARG00000095908 AllianceGenome:ZFIN:ZDB-GENE-040704-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SSAT-1; ssat1c; bZ1F1.2; zgc:91957
Summary
Enables diamine N-acetyltransferase activity. Predicted to be involved in spermidine acetylation. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See sat1a.2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (4366431..4374375)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (4033411..4041340)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 4 Neighboring gene spermidine/spermine N1-acetyltransferase 1a, duplicate 1 Neighboring gene apolipoprotein O, a Neighboring gene expressed sequence EE300746

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis. Myllymäki H, et al. Front Cell Dev Biol, 2021. PMID 34414180, Free PMC Article
  2. Duplication and diversification of the spermidine/spermine N1-acetyltransferase 1 genes in zebrafish. Lien YC, et al. PLoS One, 2013. PMID 23326562, Free PMC Article
  3. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. Chen Y, et al. Biochem J, 2003 Aug 1. PMID 12803540, Free PMC Article
  4. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Le X, et al. Development, 2013 Jun. PMID 23615277, Free PMC Article
  5. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables diamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diamine N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diamine N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables spermidine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diamine acetyltransferase 1a.2
Names
spermidine/spermine N1-acetyltransferase 1
NP_001002169.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002169.2 → NP_001002169.1  diamine acetyltransferase 1a.2

    See identical proteins and their annotated locations for NP_001002169.1

    Status: VALIDATED

    Source sequence(s)
    CABZ01046677, EH433435
    UniProtKB/TrEMBL
    B2GNJ1, Q6GQM2
    Related
    ENSDARP00000135172.1, ENSDART00000168560.3
    Conserved Domains (2) summary
    COG0456
    Location:1 → 144
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:70 → 144
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    4366431..4374375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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