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Ppn Papilin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43872, updated on 9-Dec-2024

Summary

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Official Symbol
Ppnprovided by FlyBase
Official Full Name
Papilinprovided by FlyBase
Primary source
FLYBASE:FBgn0003137
Locus tag
Dmel_CG33103
See related
AllianceGenome:FB:FBgn0003137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1540; CG18436; CG33103; CT3186; CT41988; Dmel\CG33103; ppl; ppn
Summary
An extracellular matrix structural constituent. Involved in extracellular matrix organization. Located in basement membrane. Is expressed in several structures, including adult head; adult heart; epithelial furrow; gut section; and proventriculus primordium. Orthologous to human PAPLN (papilin, proteoglycan like sulfated glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ppn in Genome Data Viewer
Location:
98D3-98D4; 3-96 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28520665..28540324, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24346387..24366046, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dynein heavy chain at 89D Neighboring gene uncharacterized protein Neighboring gene mitochondrial translation initiation factor 2 Neighboring gene fork head

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Papilin: a Drosophila proteoglycan-like sulfated glycoprotein from basement membranes. Campbell AG, et al. J Biol Chem, 1987 Dec 25. PMID 3320045
  2. Alternative splicing of papilin and the diversity of Drosophila extracellular matrix during embryonic morphogenesis. Kramerova IA, et al. Dev Dyn, 2003 Apr. PMID 12666201
  3. Secreted ADAMTS-like proteins as regulators of connective tissue function. Taye N, et al. Am J Physiol Cell Physiol, 2024 Mar 1. PMID 38284126
  4. Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila. Khodor YL, et al. Genes Dev, 2011 Dec 1. PMID 22156210, Free PMC Article
  5. Apoptotic forces in tissue morphogenesis. Ambrosini A, et al. Mech Dev, 2017 Apr. PMID 27771340

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila, which has a compact genome, expresses three splice variants of papilin during embryogenesis in developmentally defined patterns.
    Title: Alternative splicing of papilin and the diversity of Drosophila extracellular matrix during embryonic morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables extracellular matrix structural constituent IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
papilin
Names
CG33103-PC
CG33103-PE
CG33103-PF
CG33103-PG
Ppn-PC
Ppn-PE
Ppn-PF
Ppn-PG
lacunin
lacunin-like
papilin precursor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    28520665..28540324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170289.2 → NP_001163760.1  papilin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163760.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q868Z9
    Conserved Domains (8) summary
    smart00209
    Location:60 → 111
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:2042 → 2117
    IG_like; Immunoglobulin like
    pfam00014
    Location:1670 → 1721
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00090
    Location:645 → 693
    TSP_1; Thrombospondin type 1 domain
    pfam00095
    Location:1872 → 1912
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam05986
    Location:214 → 329
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:2127 → 2159
    PLAC; PLAC (protease and lacunin) domain
    cl11960
    Location:1936 → 2025
    Ig; Immunoglobulin domain

  2. NM_001170290.2 → NP_001163761.1  papilin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163761.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q868Z9
    Conserved Domains (10) summary
    cd00096
    Location:2579 → 2644
    Ig; Immunoglobulin domain
    smart00209
    Location:60 → 111
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:2709 → 2784
    IG_like; Immunoglobulin like
    cd00109
    Location:2014 → 2064
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:1670 → 1721
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00090
    Location:645 → 693
    TSP_1; Thrombospondin type 1 domain
    pfam00095
    Location:2400 → 2440
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam05986
    Location:214 → 329
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:2794 → 2826
    PLAC; PLAC (protease and lacunin) domain
    cl11960
    Location:2464 → 2553
    Ig; Immunoglobulin domain

  3. NM_176574.3 → NP_788751.2  papilin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788751.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q868Z9
    Conserved Domains (10) summary
    cd00096
    Location:2514 → 2579
    Ig; Immunoglobulin domain
    smart00209
    Location:60 → 111
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:2644 → 2719
    IG_like; Immunoglobulin like
    cd00109
    Location:2071 → 2121
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:1670 → 1721
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00090
    Location:645 → 693
    TSP_1; Thrombospondin type 1 domain
    pfam00095
    Location:2335 → 2375
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam05986
    Location:214 → 329
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:2729 → 2761
    PLAC; PLAC (protease and lacunin) domain
    cl11960
    Location:2399 → 2488
    Ig; Immunoglobulin domain

  4. NM_176575.3 → NP_788752.2  papilin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788752.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JJ05, E1JJ06, Q6NP04, Q7KRX2, Q868Z9, Q869A0, Q9GQR0, Q9VAV3, Q9VAV4
    Conserved Domains (10) summary
    cd00096
    Location:2636 → 2701
    Ig; Immunoglobulin domain
    smart00209
    Location:60 → 111
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:2766 → 2841
    IG_like; Immunoglobulin like
    cd00109
    Location:2071 → 2121
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:1670 → 1721
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00090
    Location:645 → 693
    TSP_1; Thrombospondin type 1 domain
    pfam00095
    Location:2457 → 2497
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam05986
    Location:214 → 329
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:2851 → 2883
    PLAC; PLAC (protease and lacunin) domain
    cl11960
    Location:2521 → 2610
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q868Z9.2 Q868Z9
Q95SR4 Q95SR4

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