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lds lodestar [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45894, updated on 9-Dec-2024

Summary

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Official Symbol
ldsprovided by FlyBase
Official Full Name
lodestarprovided by FlyBase
Primary source
FLYBASE:FBgn0002542
Locus tag
Dmel_CG2684
See related
AllianceGenome:FB:FBgn0002542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2684; Dmel\CG2684; DmF2; Fs(3)Hor; Fs(3)Horka; Fs(3)Sz11; Horka; Lds; lod; NTef2
Summary
Enables ATP hydrolysis activity and ATP-dependent activity, acting on DNA. Involved in several processes, including DNA-templated transcription termination; female meiotic nuclear division; and microtubule anchoring at centrosome. Located in cytoplasm and nucleus. Is expressed in organism and ovary. Orthologous to human TTF2 (transcription termination factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See lds in Genome Data Viewer
Location:
84E5-84E5; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7920431..7924491)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3746153..3750213)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA : MeU2-C41 Neighboring gene kipferl Neighboring gene uncharacterized protein Neighboring gene doublesex Neighboring gene CD98 heavy chain Neighboring gene Seminal fluid protein 84E Neighboring gene Os-C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fractionation of transcription factors for RNA polymerase II from Drosophila Kc cell nuclear extracts. Price DH, et al. J Biol Chem, 1987 Mar 5. PMID 3818640
  2. Purification of an RNA polymerase II transcript release factor from Drosophila. Xie Z, et al. J Biol Chem, 1996 May 10. PMID 8626643
  3. Drosophila factor 2, an RNA polymerase II transcript release factor, has DNA-dependent ATPase activity. Xie Z, et al. J Biol Chem, 1997 Dec 12. PMID 9395538
  4. Unusual nucleic acid binding properties of factor 2, an RNA polymerase II transcript release factor. Xie Z, et al. J Biol Chem, 1998 Feb 6. PMID 9452510
  5. Purification of P-TEFb, a transcription factor required for the transition into productive elongation. Marshall NF, et al. J Biol Chem, 1995 May 26. PMID 7759473

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription termination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule anchoring at centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lodestar
Names
CG2684-PA
early-3
early-5
early-B
factor 2
female sterile (3) horka
lds-PA
negative transcription elongation factor 2
transcript A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7920431..7924491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080111.4 → NP_524850.2  lodestar [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524850.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34739, Q9VHY1
    UniProtKB/TrEMBL
    A0A0C5K8A0
    Related
    FBpp0081255
    Conserved Domains (3) summary
    cd00046
    Location:459 → 634
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:885 → 1014
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:442 → 805
    SNF2_N; SNF2 family N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34739.2 P34739
Q8MT27 Q8MT27

Gene LinkOut

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