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Ttc7 Tetratricopeptide repeat domain 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48387, updated on 9-Dec-2024

Summary

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Official Symbol
Ttc7provided by FlyBase
Official Full Name
Tetratricopeptide repeat domain 7provided by FlyBase
Primary source
FLYBASE:FBgn0021847
Locus tag
Dmel_CG8325
See related
AllianceGenome:FB:FBgn0021847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD21719; CG8325; Dmel\CG8325; dTTC7; l(2)k14710; l(2)k15603; ttc7; TTC7; YPP1
Summary
Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to several human genes including TTC7A (tetratricopeptide repeat domain 7A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Ttc7 in Genome Data Viewer
Location:
42A13-42A13; 2-55 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6209782..6214122, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2097287..2101627, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44161 Neighboring gene bicoid-interacting protein 3 Neighboring gene tomboy40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila. Sun M, et al. J Alzheimers Dis, 2018. PMID 30103315
  2. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila. Zhang Q, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34894559
  3. A PI4KIIIα protein complex is required for cell viability during Drosophila wing development. Basu U, et al. Dev Biol, 2020 Jun 15. PMID 32194035, Free PMC Article
  4. Position Effects Influence Transvection in Drosophila melanogaster. King TD, et al. Genetics, 2019 Dec. PMID 31611231, Free PMC Article
  5. Regulation of PI4P levels by PI4KIIIα during G-protein-coupled PLC signaling in Drosophila photoreceptors. Balakrishnan SS, et al. J Cell Sci, 2018 Aug 3. PMID 29980590, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat domain 7
Names
CG8325-PA
CG8325-PB
Ttc7-PA
Ttc7-PB
lethal (2) k14710

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6209782..6214122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259218.2 → NP_001246147.1  tetratricopeptide repeat domain 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246147.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7H0
    Conserved Domains (4) summary
    COG0457
    Location:408 → 626
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:703 → 731
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:772 → 836
    TPR_11; TPR repeat
    pfam13428
    Location:772 → 814
    TPR_14; Tetratricopeptide repeat

  2. NM_143806.4 → NP_652063.1  tetratricopeptide repeat domain 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN74
    Related
    FBpp0085344
    Conserved Domains (4) summary
    COG0457
    Location:408 → 626
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:713 → 741
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:782 → 846
    TPR_11; TPR repeat
    pfam13428
    Location:782 → 824
    TPR_14; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7H0 A0A0B4K7H0
Q7KN74 Q7KN74

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