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Arts Artemis [ Drosophila melanogaster (fruit fly) ]

Gene ID: 59215, updated on 9-Dec-2024

Summary

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Official Symbol
Artsprovided by FlyBase
Official Full Name
Artemisprovided by FlyBase
Primary source
FLYBASE:FBgn0042177
Locus tag
Dmel_CG32164
See related
AllianceGenome:FB:FBgn0042177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18219; CG18860; CG32164; Dmel\CG32164
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; organism; ovary; and spermatozoon. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Arts in Genome Data Viewer
Location:
73B1-73B1; 3-44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16602851..16608146)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16596153..16601246)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene spindle defective 2 Neighboring gene Apollo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Proteasome beta6 subunit Neighboring gene Suppressor of ref(2)P sterility

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sexual conflict drive in the rapid evolution of new gametogenesis genes. VanKuren NW, et al. Semin Cell Dev Biol, 2024 Jun-Jul. PMID 38309142
  2. Gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions. VanKuren NW, et al. Nat Ecol Evol, 2018 Apr. PMID 29459709, Free PMC Article
  3. APOLLO, a testis-specific Drosophila ortholog of importin-4, mediates the loading of protamine-like protein Mst77F into sperm chromatin. Emelyanov AV, et al. J Biol Chem, 2023 Oct. PMID 37660905, Free PMC Article
  4. Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila. Borkúti P, et al. Front Mol Biosci, 2022. PMID 36060241, Free PMC Article
  5. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
artemis
Names
Arts-PA
Arts-PB
Arts-PC
CG32164-PA
CG32164-PB
CG32164-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16602851..16608146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001414077.1 → NP_001401038.1  artemis, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFR8, Q8SWQ9

  2. NM_001275028.1 → NP_001261957.1  artemis, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261957.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFR8, Q8SWQ9
    Conserved Domains (2) summary
    smart00913
    Location:29 → 90
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:356 → 384
    HEAT; HEAT repeat [structural motif]

  3. NM_168677.2 → NP_730184.1  artemis, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730184.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWQ9, Q9VV82
    Related
    FBpp0075073
    Conserved Domains (2) summary
    smart00913
    Location:29 → 90
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:355 → 383
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFR8 M9PFR8
Q8SWQ9 Q8SWQ9
Q8T094 Q8T094
Q9VV82 Q9VV82

Gene LinkOut

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