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Mrps23 mitochondrial ribosomal protein S23 [ Mus musculus (house mouse) ]

Gene ID: 64656, updated on 27-Nov-2024

Summary

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Official Symbol
Mrps23provided by MGI
Official Full Name
mitochondrial ribosomal protein S23provided by MGI
Primary source
MGI:MGI:1928138
See related
Ensembl:ENSMUSG00000023723 AllianceGenome:MGI:1928138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S23mt; Rpms23; MRP-S23; D11Bwg1153e
Summary
Predicted to be a structural constituent of ribosome. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; heart; and liver. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 46. Orthologous to human MRPS23 (mitochondrial ribosomal protein S23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 29.9), CNS E14 (RPKM 18.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrps23 in Genome Data Viewer
Location:
11 C; 11 52.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88084932..88102333)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88194106..88211507)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_30316 Neighboring gene STARR-positive B cell enhancer ABC_E8441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88047672-88047825 Neighboring gene STARR-positive B cell enhancer ABC_E7041 Neighboring gene predicted gene, 38534 Neighboring gene VISTA enhancer mm439 Neighboring gene predicted gene, 34366

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
  2. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 2310047I09Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS23
Names
28S ribosomal protein S23, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291270.1 → NP_001278199.1  small ribosomal subunit protein mS23 isoform b

    See identical proteins and their annotated locations for NP_001278199.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform.
    Source sequence(s)
    AK014375, AL593853, AW121224
    Consensus CDS
    CCDS70279.1
    UniProtKB/TrEMBL
    Q3THH3, Q3TI14
    Conserved Domains (1) summary
    pfam10484
    Location:1 → 109
    MRP-S23; Mitochondrial ribosomal protein S23

  2. NM_001291271.1 → NP_001278200.1  small ribosomal subunit protein mS23 isoform b

    See identical proteins and their annotated locations for NP_001278200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5'-terminal exon, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform.
    Source sequence(s)
    AK014375, AL593853, AW121224, BY238199, BY794322
    Consensus CDS
    CCDS70279.1
    UniProtKB/TrEMBL
    Q3THH3, Q3TI14
    Conserved Domains (1) summary
    pfam10484
    Location:1 → 109
    MRP-S23; Mitochondrial ribosomal protein S23

  3. NM_001291272.1 → NP_001278201.1  small ribosomal subunit protein mS23 isoform b

    See identical proteins and their annotated locations for NP_001278201.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform.
    Source sequence(s)
    AK014375, AW121224, BY238199, BY794322
    Consensus CDS
    CCDS70279.1
    UniProtKB/TrEMBL
    Q3THH3, Q3TI14
    Related
    ENSMUSP00000113512.2, ENSMUST00000118784.8
    Conserved Domains (1) summary
    pfam10484
    Location:1 → 109
    MRP-S23; Mitochondrial ribosomal protein S23

  4. NM_001291273.1 → NP_001278202.1  small ribosomal subunit protein mS23 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AK014375, AW121224, BY238199
    UniProtKB/TrEMBL
    F7ARZ1
    Related
    ENSMUSP00000122963.2, ENSMUST00000144070.3
    Conserved Domains (1) summary
    cl24037
    Location:2 → 73
    MRP-S25; Mitochondrial ribosomal protein S25

  5. NM_024174.6 → NP_077136.2  small ribosomal subunit protein mS23 isoform a

    See identical proteins and their annotated locations for NP_077136.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK014375, AW121224, BY238199
    Consensus CDS
    CCDS25227.1
    UniProtKB/Swiss-Prot
    Q8VE22, Q9CXH1
    UniProtKB/TrEMBL
    Q3THH3
    Related
    ENSMUSP00000024486.8, ENSMUST00000024486.14
    Conserved Domains (1) summary
    pfam10484
    Location:2 → 128
    MRP-S23; Mitochondrial ribosomal protein S23

RNA

  1. NR_111902.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 5'-terminal exon, and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK014375, AW121224, BY238199, BY794322

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    88084932..88102333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE22.1 GenPept UniProtKB/Swiss-Prot:Q8VE22

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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