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Wasf3 WASP family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 682937, updated on 27-Nov-2024

Summary

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Official Symbol
Wasf3provided by RGD
Official Full Name
WASP family member 3provided by RGD
Primary source
RGD:1592807
See related
EnsemblRapid:ENSRNOG00000048898 AllianceGenome:RGD:1592807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity. Predicted to be involved in cytoskeleton organization; modification of postsynaptic actin cytoskeleton; and regulation of cell shape. Predicted to act upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Predicted to be located in glial cell projection and lamellipodium. Predicted to be active in glutamatergic synapse and postsynapse. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 98.3), Kidney (RPKM 29.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Wasf3 in Genome Data Viewer
Location:
12p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13675642..13774648, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8563805..8660799, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10297896..10391014, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095929 Neighboring gene uncharacterized LOC134481262 Neighboring gene uncharacterized LOC134481263 Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120095890 Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene cyclin-dependent kinase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization. Pilpel Y, et al. J Neurochem, 2005 Dec. PMID 16190876
  2. WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. Kim HJ, et al. J Neurosci, 2006 May 24. PMID 16723544, Free PMC Article
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin-binding protein WASF3
Names
WAS protein family, member 3
wiskott-Aldrich syndrome protein family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427154.2 → NP_001414083.1  actin-binding protein WASF3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1D0, M0R7F3
    Related
    ENSRNOP00000065380.3, ENSRNOT00000071567.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    13675642..13774648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271653.1 → XP_063127723.1  actin-binding protein WASF3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G8L2
    Related
    ENSRNOP00000081893.1, ENSRNOT00000119900.2

  2. XM_039089936.2 → XP_038945864.1  actin-binding protein WASF3 isoform X1

    UniProtKB/TrEMBL
    A6K1D0, M0R7F3
    Conserved Domains (2) summary
    cd21762
    Location:454 → 457
    WH2; actin-binding sequence [structural motif]
    cl41728
    Location:437 → 502
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

  3. XM_063271655.1 → XP_063127725.1  actin-binding protein WASF3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G8L2

  4. XM_063271652.1 → XP_063127722.1  actin-binding protein WASF3 isoform X1

    UniProtKB/TrEMBL
    A6K1D0, M0R7F3

  5. XM_063271654.1 → XP_063127724.1  actin-binding protein WASF3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G8L2

  6. XM_039089938.2 → XP_038945866.1  actin-binding protein WASF3 isoform X3

    Conserved Domains (1) summary
    cd22073
    Location:224 → 289
    WH2_WAVE-3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 3 (WASP-3 or WAVE3)

RNA

  1. XR_010056418.1 RNA Sequence

  2. XR_010056416.1 RNA Sequence

  3. XR_010056417.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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