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Mfsd10 major facilitator superfamily domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 68294, updated on 13-Jan-2025

Summary

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Official Symbol
Mfsd10provided by MGI
Official Full Name
major facilitator superfamily domain containing 10provided by MGI
Primary source
MGI:MGI:1915544
See related
Ensembl:ENSMUSG00000001082 AllianceGenome:MGI:1915544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tetran; 0610009O03Rik
Summary
Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in apoptotic process and transmembrane transport. Predicted to act upstream of or within sodium-independent organic anion transport. Located in brush border membrane and nuclear inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human MFSD10 (major facilitator superfamily domain containing 10). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in ovary adult (RPKM 78.2), limb E14.5 (RPKM 51.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mfsd10 in Genome Data Viewer
Location:
5 B2; 5 17.9 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34790988..34794558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34633644..34637215, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene SH3-domain binding protein 2 Neighboring gene predicted gene, 22847 Neighboring gene STARR-positive B cell enhancer ABC_E3568 Neighboring gene microRNA 7036b Neighboring gene STARR-seq mESC enhancer starr_12845 Neighboring gene adducin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34979450-34979637 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:35002815-35002998 Neighboring gene NOP14 nucleolar protein Neighboring gene predicted gene 15522 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene microRNA 467g

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption. Bagchi S, et al. Int J Neurosci, 2020 May. PMID 31906755
  2. Expression and function of TETRAN, a new type of membrane transporter. Ushijima H, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18638446
  3. Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells. Cheng LC, et al. Nucleus, 2019 Dec. PMID 31142202, Free PMC Article
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
    Title: Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium-independent organic anion transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
major facilitator superfamily domain-containing protein 10
Names
tetracycline transporter-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356978.2 → NP_001343907.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    Consensus CDS
    CCDS19217.1
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8
    Related
    ENSMUSP00000109968.2, ENSMUST00000114329.8
    Conserved Domains (1) summary
    cl28910
    Location:52 → 434
    MFS; Major Facilitator Superfamily

  2. NM_001356979.2 → NP_001343908.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    Consensus CDS
    CCDS19217.1
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8
    Related
    ENSMUSP00000109970.4, ENSMUST00000114331.10
    Conserved Domains (1) summary
    cl28910
    Location:52 → 434
    MFS; Major Facilitator Superfamily

  3. NM_001412500.1 → NP_001399429.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8

  4. NM_001412501.1 → NP_001399430.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8

  5. NM_001412502.1 → NP_001399431.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8

  6. NM_001412503.1 → NP_001399432.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8

  7. NM_001412504.1 → NP_001399433.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8

  8. NM_001412505.1 → NP_001399434.1  major facilitator superfamily domain-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8

  9. NM_001412506.1 → NP_001399435.1  major facilitator superfamily domain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115695

  10. NM_001412507.1 → NP_001399436.1  major facilitator superfamily domain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115695

  11. NM_001412508.1 → NP_001399437.1  major facilitator superfamily domain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115695

  12. NM_001412509.1 → NP_001399438.1  major facilitator superfamily domain-containing protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115695

  13. NM_001412510.1 → NP_001399439.1  major facilitator superfamily domain-containing protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115695

  14. NM_001412511.1 → NP_001399440.1  major facilitator superfamily domain-containing protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115695

  15. NM_026660.4 → NP_080936.1  major facilitator superfamily domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_080936.1

    Status: VALIDATED

    Source sequence(s)
    AC115695
    Consensus CDS
    CCDS19217.1
    UniProtKB/Swiss-Prot
    Q3U800, Q3UN73, Q9D1A7, Q9D2V8
    Related
    ENSMUSP00000001109.5, ENSMUST00000001109.11
    Conserved Domains (1) summary
    cl28910
    Location:52 → 434
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34790988..34794558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254781.2 → XP_030110641.1  major facilitator superfamily domain-containing protein 10 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:1 → 257
    MFS; Major Facilitator Superfamily

  2. XM_006504079.5 → XP_006504142.1  major facilitator superfamily domain-containing protein 10 isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:1 → 241
    MFS; Major Facilitator Superfamily

  3. XM_011240768.4 → XP_011239070.1  major facilitator superfamily domain-containing protein 10 isoform X2

    See identical proteins and their annotated locations for XP_011239070.1

    UniProtKB/Swiss-Prot
    Q9D2V8
    Conserved Domains (1) summary
    cl28910
    Location:1 → 257
    MFS; Major Facilitator Superfamily

RNA

  1. XR_004942554.1 RNA Sequence

  2. XR_868298.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2V8.1 GenPept UniProtKB/Swiss-Prot:Q9D2V8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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