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sloth2 sloth 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 7354414, updated on 9-Dec-2024

Summary

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Official Symbol
sloth2provided by FlyBase
Official Full Name
sloth 2provided by FlyBase
Primary source
FLYBASE:FBgn0259204
Locus tag
Dmel_CG42308
See related
AllianceGenome:FB:FBgn0259204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14428; CG42308; Dmel\CG42308; Sloth2
Summary
Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in adult head and organism. Orthologous to human UQCC6 (ubiquinol-cytochrome c reductase complex assembly factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See sloth2 in Genome Data Viewer
Location:
6E4-6E4; 1-18 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7011357..7012137)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6905390..6906170)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Innexin 2 Neighboring gene carmine Neighboring gene sloth 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. Bosch JA, et al. Elife, 2022 Nov 8. PMID 36346220, Free PMC Article
  2. Gene Knock-Ins in Drosophila Using Homology-Independent Insertion of Universal Donor Plasmids. Bosch JA, et al. Genetics, 2020 Jan. PMID 31685521, Free PMC Article
  3. Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models. Brischigliaro M, et al. Biomolecules, 2023 Feb 16. PMID 36830747, Free PMC Article
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex III assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sloth 2
Names
CG42308-PA
CG42308-PB
sloth2-PA
sloth2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7011357..7012137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144699.2 → NP_001138171.1  sloth 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0X7
    Conserved Domains (1) summary
    pfam14990
    Location:2 → 44
    DUF4516; Domain of unknown function (DUF4516)

  2. NM_001144700.3 → NP_001138172.1  sloth 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0X7
    Conserved Domains (1) summary
    pfam14990
    Location:2 → 44
    DUF4516; Domain of unknown function (DUF4516)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z0X7 B7Z0X7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials