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YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [ Homo sapiens (human) ]

Gene ID: 7529, updated on 27-Nov-2024

Summary

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Official Symbol
YWHABprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaprovided by HGNC
Primary source
HGNC:HGNC:12849
See related
Ensembl:ENSG00000166913 MIM:601289; AllianceGenome:HGNC:12849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
Summary
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues See more
Orthologs
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Genomic context

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See YWHAB in Genome Data Viewer
Location:
20q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44885705..44908532)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46621568..46644395)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43514346..43537173)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43380582-43381129 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:43385377-43386576 Neighboring gene potassium two pore domain channel subfamily K member 15 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:43401277-43401777 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:43405721-43405858 Neighboring gene piggyBac transposable element derived 4 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12948 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:43514076-43514692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545042-43545542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545543-43546043 Neighboring gene poly(A) binding protein cytoplasmic 1 like Neighboring gene uncharacterized LOC124904912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17941 Neighboring gene translocase of outer mitochondrial membrane 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. 14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway. Seo SB, et al. Mol Neurobiol, 2018 Feb. PMID 28116547
  2. 14-3-3 protein binds to the low molecular weight neurofilament (NFL) mRNA 3' UTR. Ge WW, et al. Mol Cell Neurosci, 2007 Jan. PMID 17098443
  3. Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia. Middleton FA, et al. Neuropsychopharmacology, 2005 May. PMID 15726117
  4. Lack of association between 14-3-3 beta gene (YWHAB) polymorphisms and sporadic Creutzfeldt-Jakob disease (CJD). Jeong BH, et al. Mol Biol Rep, 2012 Dec. PMID 23053962
  5. 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove. Rodriguez LG, et al. J Cell Physiol, 2005 Jan. PMID 15389601

See all (475) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.
    Title: miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.
  2. 14-3-3beta isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
    Title: 14-3-3β isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
  3. Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.
    Title: Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.
  4. Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.
    Title: Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.
  5. The regulatory protein 14-3-3beta binds to the IQ motifs of myosin-IC independent of phosphorylation.
    Title: The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.
  6. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization and its activity.
    Title: YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
  7. YWHAB was identified and validated in association with pulmonary arterial hypertension progression, which might serve as a biomarker and/or therapeutic target for pulmonary arterial hypertension.
    Title: Integrated bioinformatic analysis reveals YWHAB as a novel diagnostic biomarker for idiopathic pulmonary arterial hypertension.
  8. the interaction of lncRNA RP11-732M18.3 with 14-3-3beta/alpha increases the degradation of the p21 protein. lncRNA RP11-732M18.3 promoted the recruitment of ubiquitin-conjugating enzyme E2 E1 to 14-3-3beta/alpha and the binding of 14-3-3beta/alpha with ubiquitin-conjugating enzyme E2 E1 (UBE2E1) promoted the degradation of p21.
    Title: The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growth.
  9. 14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis.
    Title: Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
  10. findings advance our understanding of how phosphorylation of lipin 1beta phosphatidate phosphatase regulates its interaction with 14-3-3beta protein and intracellular localization and uncover a mechanism by which CKII regulates cellular physiology.
    Title: Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of WASF2 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with 14-3-3 protein beta/alpha (YWHAB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoserine residue binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic sequestering of protein IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
14-3-3 protein beta/alpha
Names
14-3-3 alpha
epididymis secretory protein Li 1
protein 1054
protein kinase C inhibitor protein-1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003404.5 → NP_003395.1  14-3-3 protein beta/alpha

    See identical proteins and their annotated locations for NP_003395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AA845374, AK292717, AL008725, DB443535
    Consensus CDS
    CCDS13339.1
    UniProtKB/Swiss-Prot
    A8K9K2, E1P616, P31946
    UniProtKB/TrEMBL
    B5BU24, V9HWD6
    Related
    ENSP00000361930.3, ENST00000372839.7
    Conserved Domains (1) summary
    cd10022
    Location:4 → 232
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

  2. NM_139323.4 → NP_647539.1  14-3-3 protein beta/alpha

    See identical proteins and their annotated locations for NP_647539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AA845374, AL008725, BC001359, DB443535
    Consensus CDS
    CCDS13339.1
    UniProtKB/Swiss-Prot
    A8K9K2, E1P616, P31946
    UniProtKB/TrEMBL
    B5BU24, V9HWD6
    Related
    ENSP00000300161.4, ENST00000353703.9
    Conserved Domains (1) summary
    cd10022
    Location:4 → 232
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    44885705..44908532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028040.2 → XP_016883529.1  14-3-3 protein beta/alpha isoform X1

    UniProtKB/TrEMBL
    Q4VY19
    Related
    ENSP00000394729.1, ENST00000428262.1
    Conserved Domains (1) summary
    cl02098
    Location:4 → 100
    14-3-3; 14-3-3 domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    46621568..46644395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323962.1 → XP_054179937.1  14-3-3 protein beta/alpha isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31946.3 GenPept UniProtKB/Swiss-Prot:P31946

Gene LinkOut

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