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Desi2 desumoylating isopeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 78825, updated on 27-Nov-2024

Summary

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Official Symbol
Desi2provided by MGI
Official Full Name
desumoylating isopeptidase 2provided by MGI
Primary source
MGI:MGI:1926075
See related
Ensembl:ENSMUSG00000026502 AllianceGenome:MGI:1926075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DeSI-2; Pppde1; Fam152a; 5830417C01Rik
Summary
Predicted to enable deubiquitinase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in macromolecule depalmitoylation and proteolysis. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; muscle tissue; and spleen. Orthologous to human DESI2 (desumoylating isopeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 5.4), bladder adult (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Desi2 in Genome Data Viewer
Location:
1 H4; 1 82.93 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178014983..178080164)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178187417..178252598)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit epsilon 2 Neighboring gene predicted gene, 25312 Neighboring gene STARR-seq mESC enhancer starr_03139 Neighboring gene STARR-positive B cell enhancer ABC_E4396 Neighboring gene translin-associated factor X pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:180115890-180116191 Neighboring gene STARR-positive B cell enhancer ABC_E2023 Neighboring gene STARR-seq mESC enhancer starr_03140 Neighboring gene STARR-positive B cell enhancer mm9_chr1:180172365-180172665 Neighboring gene RIKEN cDNA 4930527J03 gene Neighboring gene STARR-seq mESC enhancer starr_03141 Neighboring gene predicted gene 8023

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comprehensive analysis of expression profile reveals the ubiquitous distribution of PPPDE peptidase domain 1, a Golgi apparatus component, and its implications in clinical cancer. He Y, et al. Biochimie, 2013 Jul. PMID 23567336
  2. PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain. Cai P, et al. Mol Biol Rep, 2012 Jan. PMID 21553223
  3. A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. Yan F, et al. Biochimie, 2009 Apr. PMID 19133312
  4. DeSUMOylating isopeptidase: a second class of SUMO protease. Shin EJ, et al. EMBO Rep, 2012 Apr. PMID 22370726, Free PMC Article
  5. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. expression regulation and biological functions of PPPDE1 in development and carcinogenesis.
    Title: Comprehensive analysis of expression profile reveals the ubiquitous distribution of PPPDE peptidase domain 1, a Golgi apparatus component, and its implications in clinical cancer.
  2. PNAS4 was not involved in mice brain development and apoptosis.
    Title: PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain.
  3. overexpression of mouse PNAS4 significantly suppressed Lewis lung carcinoma growth and prolonged survival time through induction of tumor cell apoptosis
    Title: A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • DKFZp586C1019

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in macromolecule depalmitoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
deubiquitinase DESI2
Names
PPPDE peptidase domain containing 1
PPPDE peptidase domain-containing protein 1
S-depalmitoylase DESI2
family with sequence similarity 152, member A
palmitoyl protein thioesterase DESI2
NP_077244.1
XP_030099574.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024282.3 → NP_077244.1  deubiquitinase DESI2

    See identical proteins and their annotated locations for NP_077244.1

    Status: VALIDATED

    Source sequence(s)
    AC119928, AK029574, AK049579
    Consensus CDS
    CCDS35803.1
    UniProtKB/Swiss-Prot
    Q3TUJ4, Q9D291
    UniProtKB/TrEMBL
    Q3UJE4
    Related
    ENSMUSP00000027783.8, ENSMUST00000027783.14
    Conserved Domains (1) summary
    pfam05903
    Location:7 → 149
    Peptidase_C97; PPPDE putative peptidase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    178014983..178080164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243714.2 → XP_030099574.1  deubiquitinase DESI2 isoform X1

    UniProtKB/TrEMBL
    Q3UJE4, Q8BIB9
    Related
    ENSMUSP00000124658.2, ENSMUST00000161075.8
    Conserved Domains (1) summary
    pfam05903
    Location:4 → 133
    Peptidase_C97; PPPDE putative peptidase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D291.1 GenPept UniProtKB/Swiss-Prot:Q9D291

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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