U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PAS1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824568, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
PAS1
Official Full Name
FKBP-type peptidyl-prolyl cis-trans isomerase family protein
Primary source
TAIR:AT3G54010
Locus tag
AT3G54010
See related
Araport:AT3G54010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DEI1; PASTICCINO 1
Summary
Immunophilin-like protein similar to the p59 FK506-binding protein (FKBP52). Shows rotamase activity and contains an FKBP-like domain and three tetratricopeptide repeat units. Members of this class of mutation show ectopic cell proliferation in cotyledons. Gene may be alternatively spliced. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PAS1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
20
Sequence:
Chromosome: 3; NC_003074.8 (20000821..20005280)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene TIP41-like protein Neighboring gene Inositol phosphorylceramide synthase 1 Neighboring gene kinase with tetratricopeptide repeat domain-containing protein Neighboring gene PAR1 protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis. Roudier F, et al. Plant Cell, 2010 Feb. PMID 20145257, Free PMC Article
  2. Mutation in the Arabidopsis PASTICCINO1 gene, which encodes a new FK506-binding protein-like protein, has a dramatic effect on plant development. Vittorioso P, et al. Mol Cell Biol, 1998 May. PMID 9566922, Free PMC Article
  3. The C terminus of the immunophilin PASTICCINO1 is required for plant development and for interaction with a NAC-like transcription factor. Smyczynski C, et al. J Biol Chem, 2006 Sep 1. PMID 16803883
  4. The PASTICCINO genes of Arabidopsis thaliana are involved in the control of cell division and differentiation. Faure JD, et al. Development, 1998 Mar. PMID 9449673
  5. Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Geisler M, et al. Mol Biol Cell, 2004 Jul. PMID 15133126, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAS1 regulates the function of the NAC-like transcription factor by controlling its targeting to the nucleus upon plant cell division
    Title: The C terminus of the immunophilin PASTICCINO1 is required for plant development and for interaction with a NAC-like transcription factor.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_115261.4
NM_180370.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lateral root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cytokinin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
FKBP-type peptidyl-prolyl cis-trans isomerase family protein
NP_566993.1
  • PASTICCINO 1 (PAS1); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, binding; INVOLVED IN: in 9 processes; LOCATED IN: endoplasmic reticulum, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: rotamase FKBP 1 (TAIR:AT3G25230.2); Has 6940 Blast hits to 5854 proteins in 534 species: Archae - 36; Bacteria - 500; Metazoa - 3344; Fungi - 737; Plants - 1066; Viruses - 0; Other Eukaryotes - 1257 (source: NCBI BLink).
NP_850701.1
  • PASTICCINO 1 (PAS1); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, binding; INVOLVED IN: in 9 processes; LOCATED IN: endoplasmic reticulum, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: rotamase FKBP 1 (TAIR:AT3G25230.2); Has 6249 Blast hits to 5494 proteins in 451 species: Archae - 36; Bacteria - 312; Metazoa - 2945; Fungi - 683; Plants - 1187; Viruses - 0; Other Eukaryotes - 1086 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20000821..20005280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115261.4 → NP_566993.1  FKBP-type peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64403, Q7DMA9, Q93ZT7, Q9M326
    UniProtKB/TrEMBL
    A0A5S9XLE3, A0A7G2ER31
    Conserved Domains (4) summary
    sd00006
    Location:437 → 478
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:44 → 144
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:399 → 480
    TPR_11; TPR repeat
    cl19519
    Location:168 → 257
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. NM_180370.3 → NP_850701.1  FKBP-type peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850701.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XLE3, A0A7G2ER31
    Conserved Domains (4) summary
    sd00006
    Location:347 → 388
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:201 → 290
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:309 → 390
    TPR_11; TPR repeat
    cl19519
    Location:1 → 54
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7DMA9.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools