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CBL cystathionine beta-lyase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824872, updated on 18-Sep-2024

Summary

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Official Symbol
CBL
Official Full Name
cystathionine beta-lyase
Primary source
TAIR:AT3G57050
Locus tag
AT3G57050
See related
Araport:AT3G57050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
cystathionine beta-lyase
Summary
Encodes second enzyme in the methionine biosynthetic pathway
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Genomic context

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See CBL in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Sequence:
Chromosome: 3; NC_003074.8 (21111700..21114737, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene response regulator 9 Neighboring gene binding protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cystathionine beta-lyase is crucial for embryo patterning and the maintenance of root stem cell niche in Arabidopsis. Liu G, et al. Plant J, 2019 Aug. PMID 31002461
  2. Cloning of an Arabidopsis thaliana cDNA encoding cystathionine beta-lyase by functional complementation in Escherichia coli. Ravanel S, et al. Plant Mol Biol, 1995 Nov. PMID 8541513
  3. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
  4. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
  5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that cystathionine beta-lyase (cbl) mutant has impaired embryo patterning, defective root stem cell niche and stunted root growth.
    Title: Cystathionine beta-lyase is crucial for embryo patterning and the maintenance of root stem cell niche in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001339838.1
NM_001339839.1
NM_115564.4
NM_180381.3
NM_180382.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-S-conjugate beta-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-S-conjugate beta-lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' L-methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-methionine biosynthetic process from L-homoserine via cystathionine TAS
Traceable Author Statement
more info
 PubMed 
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
cystathionine beta-lyase
NP_191264.1
  • cystathionine beta-lyase (CBL); FUNCTIONS IN: cystathionine beta-lyase activity; INVOLVED IN: L-methionine biosynthetic process from L-homoserine via cystathionine; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cystathionine beta-lyase, eukaryotic (InterPro:IPR006238), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT3G01120.1); Has 21174 Blast hits to 21168 proteins in 2454 species: Archae - 221; Bacteria - 12373; Metazoa - 223; Fungi - 823; Plants - 274; Viruses - 1; Other Eukaryotes - 7259 (source: NCBI BLink).
NP_850712.1
  • cystathionine beta-lyase (CBL); FUNCTIONS IN: cystathionine beta-lyase activity; INVOLVED IN: L-methionine biosynthetic process from L-homoserine via cystathionine; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Cystathionine beta-lyase, eukaryotic (InterPro:IPR006238), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT3G01120.1); Has 21173 Blast hits to 21167 proteins in 2454 species: Archae - 221; Bacteria - 12375; Metazoa - 223; Fungi - 823; Plants - 274; Viruses - 1; Other Eukaryotes - 7256 (source: NCBI BLink).
NP_850713.1
  • cystathionine beta-lyase (CBL); FUNCTIONS IN: cystathionine beta-lyase activity; INVOLVED IN: L-methionine biosynthetic process from L-homoserine via cystathionine; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Cystathionine beta-lyase, eukaryotic (InterPro:IPR006238), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT3G01120.1); Has 20092 Blast hits to 20089 proteins in 2449 species: Archae - 218; Bacteria - 12272; Metazoa - 204; Fungi - 782; Plants - 267; Viruses - 1; Other Eukaryotes - 6348 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    21111700..21114737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180381.3 → NP_850712.1  cystathionine beta-lyase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FH56
    Conserved Domains (1) summary
    PLN02509
    Location:1 → 449
    PLN02509; cystathionine beta-lyase

  2. NM_115564.4 → NP_191264.1  cystathionine beta-lyase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191264.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53780, Q8VZL8
    UniProtKB/TrEMBL
    A0A5S9XLM1, A0A654FH56, B9DGA0
    Conserved Domains (1) summary
    PLN02509
    Location:1 → 464
    PLN02509; cystathionine beta-lyase

  3. NM_180382.1 → NP_850713.1  cystathionine beta-lyase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850713.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FH56, F4J244
    Conserved Domains (1) summary
    cl18945
    Location:1 → 372
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  4. NM_001339838.1 → NP_001326867.1  cystathionine beta-lyase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LQK6, A0A654FH56

  5. NM_001339839.1 → NP_001326868.1  cystathionine beta-lyase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LQK7, A0A654FH56
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53780.1

Gene LinkOut

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