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EIF3A eukaryotic translation initiation factor 3A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826746, updated on 18-Sep-2024

Summary

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Official Symbol
EIF3A
Official Full Name
eukaryotic translation initiation factor 3A
Primary source
TAIR:AT4G11420
Locus tag
AT4G11420
See related
Araport:AT4G11420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATEIF3A-1; ATTIF3A1; EIF3A-1; eukaryotic translation initiation factor 3A; F25E4.40; F25E4_40; TIF3A1
Summary
Encodes a subunit of eukaryotic initiation factor 3 (eIF3), a multisubunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilization of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits.
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Genomic context

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See EIF3A in Genome Data Viewer
Location:
chromosome: 4
Exon count:
14
Sequence:
Chromosome: 4; NC_003075.7 (6947476..6952479, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new plant protein interacts with eIF3 and 60S to enhance virus-activated translation re-initiation. Thiébeauld O, et al. EMBO J, 2009 Oct 21. PMID 19745810, Free PMC Article
  2. Plant initiation factor 3 subunit composition resembles mammalian initiation factor 3 and has a novel subunit. Burks EA, et al. J Biol Chem, 2001 Jan 19. PMID 11042177
  3. Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Kim TH, et al. Plant Cell, 2004 Dec. PMID 15548739, Free PMC Article
  4. Characterization of a phosphatase 2C protein as an interacting partner of the histone acetyltransferase GCN5 in Arabidopsis. Servet C, et al. Biochim Biophys Acta, 2008 Jun-Jul. PMID 18498779
  5. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_117213.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within translational initiation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3A
NP_192881.1
  • eukaryotic translation initiation factor 3A (EIF3A); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: eukaryotic translation initiation factor 3 complex, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT4G23330.1); Has 151795 Blast hits to 76455 proteins in 3156 species: Archae - 1231; Bacteria - 22686; Metazoa - 70860; Fungi - 11049; Plants - 6472; Viruses - 438; Other Eukaryotes - 39059 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    6947476..6952479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117213.4 → NP_192881.1  eukaryotic translation initiation factor 3A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192881.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LD55
    UniProtKB/TrEMBL
    A0A178V400, A0A654FN84, Q0WW10
    Conserved Domains (2) summary
    PTZ00121
    Location:559 → 841
    PTZ00121; MAEBL; Provisional
    pfam01399
    Location:434 → 509
    PCI; PCI domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LD55.1

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