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HAP1 Hap1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850958, updated on 9-Dec-2024

Summary

Official Symbol
HAP1
Official Full Name
Hap1p
Primary source
SGD:S000004246
Locus tag
YLR256W
See related
AllianceGenome:SGD:S000004246; FungiDB:YLR256W; VEuPathDB:YLR256W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CYP1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; establishment of protein localization to chromatin; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See HAP1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (646415..650923)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ndl1p Neighboring gene uncharacterized protein Neighboring gene gag protein Neighboring gene tRNA-Ala

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in mitochondrion PubMed 
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
Hap1p
NP_013357.1
  • Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    646415..650923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182143.1 → NP_013357.1  TPA: Hap1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013357.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYQ2, P0CE41, P0CS82
    Conserved Domains (3) summary
    cd12148
    Location:476 → 814
    fungal_TF_MHR; fungal transcription factor regulatory middle homology region
    smart00066
    Location:59 → 99
    GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
    cd14655
    Location:99 → 130
    ZIP_Hap1; Leucine zipper Dimerization domain of transcription factor Hap1 and similar fungal proteins
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