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RSO55 Rso55p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850987, updated on 9-Dec-2024

Summary

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Official Symbol
RSO55
Official Full Name
Rso55p
Primary source
SGD:S000004271
Locus tag
YLR281C
See related
AllianceGenome:SGD:S000004271; FungiDB:YLR281C; VEuPathDB:YLR281C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PTH3
Summary
Enables aminoacyl-tRNA hydrolase activity. Involved in mitochondrial translation. Is active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 7 and hereditary spastic paraplegia 55. Orthologous to human MTRFR (mitochondrial translation release factor in rescue). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RSO55 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (704493..704960, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cleavage polyadenylation factor subunit YSH1 Neighboring gene uncharacterized protein Neighboring gene Put7p Neighboring gene dodecenoyl-CoA isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae. Hoshino S, et al. Commun Biol, 2021 Mar 8. PMID 33686140, Free PMC Article
  2. Assessing systems properties of yeast mitochondria through an interaction map of the organelle. Perocchi F, et al. PLoS Genet, 2006 Oct 20. PMID 17054397, Free PMC Article
  3. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
  4. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Fromont-Racine M, et al. Yeast, 2000 Jun 30. PMID 10900456, Free PMC Article
  5. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aminoacyl-tRNA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation release factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rso55p
NP_013383.1
  • Stalled-ribosome rescue factor srRF2; mitochondrial protein required for respiratory growth in presence of bacteriostatic ribosome-binding antibiotics; not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    704493..704960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182168.1 → NP_013383.1  TPA: Rso55p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013383.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYS6, Q05863
    UniProtKB/TrEMBL
    A7A1G3, B3RHG1, C7GVT1, C8ZDP4, N1NZY2
    Conserved Domains (1) summary
    COG1186
    Location:1 → 152
    PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05863.1

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