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CAC2 Cac2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854869, updated on 4-Jan-2025

Summary

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Official Symbol
CAC2
Official Full Name
Cac2p
Primary source
SGD:S000004570
Locus tag
YML102W
See related
AllianceGenome:SGD:S000004570; FungiDB:YML102W; VEuPathDB:YML102W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in chromosome, centromeric region; cytosol; and nucleus. Part of CAF-1 complex. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CAC2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (68294..69700)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Nup188p Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Cue4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Kaufman PD, et al. Genes Dev, 1997 Feb 1. PMID 9030687
  2. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. Mattiroli F, et al. Sci Rep, 2017 Apr 18. PMID 28418026, Free PMC Article
  3. Yeast ASF1 protein is required for cell cycle regulation of histone gene transcription. Sutton A, et al. Genetics, 2001 Jun. PMID 11404324, Free PMC Article
  4. Histone H3 N-terminal acetylation sites especially K14 are important for rDNA silencing and aging. Xu HH, et al. Sci Rep, 2016 Feb 24. PMID 26906758, Free PMC Article
  5. The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast. Brachet E, et al. PLoS One, 2015. PMID 25938567, Free PMC Article

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication-dependent chromatin assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication-dependent chromatin assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CAF-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAF-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cac2p
NP_013605.1
  • Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    68294..69700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182464.1 → NP_013605.1  TPA: Cac2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013605.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0I2, Q04199
    UniProtKB/TrEMBL
    A6ZLW2, B3LLF6, N1P0G0
    Conserved Domains (2) summary
    sd00039
    Location:17 → 69
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:4 → 214
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04199.1

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