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TFC8 transcription factor TFIIIC subunit TFC8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856100, updated on 9-Dec-2024

Summary

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Official Symbol
TFC8
Official Full Name
transcription factor TFIIIC subunit TFC8
Primary source
SGD:S000005928
Locus tag
YPL007C
See related
AllianceGenome:SGD:S000005928; FungiDB:YPL007C; VEuPathDB:YPL007C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA binding activity, bending; RNA polymerase III type 1 promoter sequence-specific DNA binding activity; and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TFC8 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (542082..543848, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rqc2p Neighboring gene DNA helicase Neighboring gene sphingolipid transporter Neighboring gene Aep3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC. Mylona A, et al. Protein Expr Purif, 2006 Feb. PMID 16115780
  2. Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly. Mylona A, et al. Mol Cell, 2006 Oct 20. PMID 17052456
  3. The two DNA-binding domains of yeast transcription factor tau as observed by scanning transmission electron microscopy. Schultz P, et al. EMBO J, 1989 Dec 1. PMID 2684647, Free PMC Article
  4. A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein. Deprez E, et al. Mol Cell Biol, 1999 Dec. PMID 10567530, Free PMC Article
  5. On the subunit composition, stoichiometry, and phosphorylation of the yeast transcription factor TFIIIC/tau. Conesa C, et al. J Biol Chem, 1993 Aug 25. PMID 7688737

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor TFIIIC subunit TFC8
NP_015318.1
  • Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    542082..543848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183821.1 → NP_015318.1  TPA: transcription factor TFIIIC subunit TFC8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015318.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W405, Q12308
    UniProtKB/TrEMBL
    A6ZWN9, B3LL55, B5VTF5, C7GV51, C8ZJ19, N1NXE3
    Conserved Domains (2) summary
    sd00039
    Location:88 → 122
    7WD40; WD40 repeat [structural motif]
    pfam12660
    Location:515 → 585
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12308.1

Gene LinkOut

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