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DSS4 guanine nucleotide exchange factor DSS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856128, updated on 9-Dec-2024

Summary

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Official Symbol
DSS4
Official Full Name
guanine nucleotide exchange factor DSS4
Primary source
SGD:S000006221
Locus tag
YPR017C
See related
AllianceGenome:SGD:S000006221; FungiDB:YPR017C; VEuPathDB:YPR017C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables guanyl-nucleotide exchange factor activity and zinc ion binding activity. Involved in post-Golgi vesicle-mediated transport. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DSS4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (593486..593917, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene translation initiation factor 6 Neighboring gene Rlf2p Neighboring gene MCM DNA helicase complex subunit MCM4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cycle of SEC4 function in vesicular transport. Novick P, et al. Ciba Found Symp, 1993. PMID 8299422
  2. Distinct subclasses of small GTPases interact with guanine nucleotide exchange factors in a similar manner. Day GJ, et al. Mol Cell Biol, 1998 Dec. PMID 9819430, Free PMC Article
  3. Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins. Esters H, et al. J Mol Biol, 2001 Jun 29. PMID 11419942
  4. Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast. Collins RN, et al. J Biol Chem, 1997 Jul 18. PMID 9218467
  5. DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function. Moya M, et al. Nature, 1993 Feb 4. PMID 8429886

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in post-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-Golgi vesicle-mediated transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor DSS4
NP_015342.1
  • Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    593486..593917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184114.1 → NP_015342.1  TPA: guanine nucleotide exchange factor DSS4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015342.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W427, P32601, Q12299, Q3S1N1
    UniProtKB/TrEMBL
    A6ZWR0, B3LL78, C7GQC1, C8ZJ42, G2WPJ5, N1NW81
    Conserved Domains (1) summary
    cd00246
    Location:2 → 136
    RabGEF; Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32601.2

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