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mexE resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 880212, updated on 24-Aug-2024

Summary

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Gene symbol
mexE
Gene description
resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE
Locus tag
PA2493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (2808743..2809987)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene oxidoreductase Neighboring gene transcriptional regulator MexT Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux transporter MexF Neighboring gene multidrug efflux outer membrane protein OprN Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump. Tian ZX, et al. Microb Pathog, 2009 Oct. PMID 19683048
  2. Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa. Maseda H, et al. FEMS Microbiol Lett, 2010 Oct. PMID 20727012
  3. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. Linares JF, et al. J Bacteriol, 2005 Feb. PMID 15687203, Free PMC Article
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription of the mexEF-oprN multidrug efflux pump operon is regulated by MexT.
    Title: Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa.
  2. The data presented suggest that MexT regulates diverse targets that mediate phenotypic alterations independent of MexEF-OprN.
    Title: MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump.
  3. overproduction of either MexCD-OprJ or MexEF-results presented here indicate that the transcriptional activation of the T3S regulon is reduced in mutants overexpressing either the MexCD-OprJ or MexEF-OprN MDR pump, making these mutants less cytotoxic
    Title: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.
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General gene information

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Homology

General protein information

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Preferred Names
resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE
NP_251183.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2808743..2809987
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_251183.1 resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_251183.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    P95421
    Conserved Domains (1) summary
    TIGR01730
    Location:39 → 369
    RND_mfp; RND family efflux transporter, MFP subunit
Nucleotide Protein
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