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hyaB hydrogenase 1 large subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945580, updated on 3-Dec-2024

Summary

Official Symbol
hyaB
Official Full Name
hydrogenase 1 large subunit
Primary source
ECOCYC:EG10469
Locus tag
b0973
See related
ASAP:ABE-0003288
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0964
Summary
HyaB is co-exported bound to TAT substrate HyaA. [More information is available at EcoGene: EG10469]. HyaB is the large subunit of hydrogenase 1; it is thought to bind the Ni-Fe active site cofactor. [More information is available at EcoCyc: EG10469].
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Genomic context

Sequence:
NC_000913.3 (1033254..1035047)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene modulator of FtsH protease Neighboring gene tRNA-Ser Neighboring gene hydrogenase 1 small subunit Neighboring gene hydrogenase 1 cytochrome b subunit Neighboring gene putative hydrogenase 1 maturation protease HyaD Neighboring gene putative HyaA chaperone Neighboring gene protein HyaF

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ferredoxin hydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrogenase (acceptor) activity IC
Inferred by Curator
more info
PubMed 
enables hydrogenase (acceptor) activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nickel cation binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nickel cation binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of [Ni-Fe] hydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of [Ni-Fe] hydrogenase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of [Ni-Fe] hydrogenase complex RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 
located_in periplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hydrogenase 1 large subunit
NP_415492.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1033254..1035047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415492.1 hydrogenase 1 large subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415492.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAI9GXY8, A0AAN5ZI55
    Conserved Domains (1) summary
    PRK10170
    Location:1597
    PRK10170; Ni/Fe-hydrogenase large subunit