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bioH pimeloyl-acyl carrier protein methyl ester esterase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947916, updated on 17-Dec-2024

Summary

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Official Symbol
bioH
Official Full Name
pimeloyl-acyl carrier protein methyl ester esterase
Primary source
ECOCYC:EG10122
Locus tag
b3412
See related
ASAP:ABE-0011136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bioB; ECK3399
Summary
S. marcescens bioH complements Escherichia coli bioH. [More information is available at EcoGene: EG10122]. BioH exhibits carboxylesterase activity, particularly toward substrates with short acyl chains . [More information is available at EcoCyc: EG10122].
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Genomic context

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Sequence:
NC_000913.3 (3544074..3544844, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Fe(2(+)) transporter FeoB Neighboring gene ferrous iron transport protein FeoC Neighboring gene recombination-promoting nuclease RpnA Neighboring gene DNA utilization protein YhgH Neighboring gene iron-sulfur cluster carrier protein NfuA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene cloning, expression, and characterization of a new carboxylesterase from Serratia sp. SES-01: comparison with Escherichia coli BioHe enzyme. Kwon MA, et al. J Microbiol Biotechnol, 2009 Feb. PMID 19307763
  2. Improving simvastatin bioconversion in Escherichia coli by deletion of bioH. Xie X, et al. Metab Eng, 2007 Jul. PMID 17625941
  3. The Serratia marcescens bioH gene encodes an esterase. Akatsuka H, et al. Gene, 2003 Jan 2. PMID 12527210
  4. Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis. Agarwal V, et al. Proc Natl Acad Sci U S A, 2012 Oct 23. PMID 23045647, Free PMC Article
  5. Origin of carbon atoms of biotin. 13C-NMR studies on biotin biosynthesis in Escherichia coli. Ifuku O, et al. Eur J Biochem, 1994 Mar 1. PMID 8125118

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylic ester hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables pimelyl-[acyl-carrier protein] methyl ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pimelyl-[acyl-carrier protein] methyl ester esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pimelyl-[acyl-carrier protein] methyl ester esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biotin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biotin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biotin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pimeloyl-acyl carrier protein methyl ester esterase
NP_417871.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3544074..3544844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417871.1 pimeloyl-acyl carrier protein methyl ester esterase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417871.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7TCT8
    Conserved Domains (1) summary
    PRK10349
    Location:1 → 256
    PRK10349; pimeloyl-ACP methyl ester esterase BioH
Nucleotide Protein
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