Replication interactions
Interaction |
Pubs |
HIV-1 NL4-3 replication is restricted by HDGFRP2 as enhanced replication was discovered when HDGFRP2 is deleted through CRISPR/Cas9 genome editing in primary CD4+ T cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Vpr
|
vpr
|
Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro |
PubMed
|
integrase
|
gag-pol
|
Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro |
PubMed
|
|
gag-pol
|
Knockdown of HRP-2 by siRNA in LEDGF/p75-depleted cells reduces integration frequency in transcription units and shifts the integration distribution towards random |
PubMed
|
|
gag-pol
|
HRP-2 functions as a co-factor of HIV-1 IN in LEDGF/p75-depleted cells. HRP-2 overexpression rescues HIV-1 replication and restored integration in genes to wild-type levels |
PubMed
|
|
gag-pol
|
Hepatoma-derived growth factor-related protein 2 translocates HIV-1 integrase from the cytoplasm to the nucleus where both proteins co-localize |
PubMed
|
matrix
|
gag
|
Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro |
PubMed
|
reverse transcriptase
|
gag-pol
|
Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro |
PubMed
|
Go to the HIV-1, Human Interaction Database