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    rictor rapamycin-insensitive companion of Tor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32919, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rictorprovided by FlyBase
    Official Full Name
    rapamycin-insensitive companion of Torprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031006
    Locus tag
    Dmel_CG8002
    See related
    AllianceGenome:FB:FBgn0031006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8002; CG8002; Dmel\CG8002; dRic; dRictor; dRICTOR; Rictor; RICTOR
    Summary
    Enables protein serine/threonine kinase activator activity. Involved in several processes, including TORC2 signaling; positive regulation of cell size; and positive regulation of signal transduction. Part of TORC2 complex. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rictor in Genome Data Viewer
    Location:
    18B6-18B6; 1-62 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19252111..19261240, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19146144..19155273, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate 3-O sulfotransferase-B Neighboring gene Vav guanine nucleotide exchange factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heat tolerance in Drosophila melanogaster is influenced by oxygen conditions and mutations in cell size control pathways. Privalova V, et al. Philos Trans R Soc Lond B Biol Sci, 2024 Feb 26. PMID 38186282,
    2. Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators. Privalova V, et al. Sci Rep, 2023 May 9. PMID 37160985, Free PMC Article
    3. TORC2: a novel target for treating age-associated memory impairment. Johnson JL, et al. Sci Rep, 2015 Oct 22. PMID 26489398, Free PMC Article
    4. An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. Shimono K, et al. Sci Rep, 2014 Mar 19. PMID 24643112, Free PMC Article
    5. The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD. Li Y, et al. J Biol Chem, 2023 Mar. PMID 36764521, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
      Title: The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway.
    2. We found that neither S6K-dependent cell growth nor S6K-Thr-398 phosphorylation was affected in rictor-null mutants.
      Title: Discrete functions of rictor and raptor in cell growth regulation in Drosophila.
    3. Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling
      Title: Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
    4. results suggest that dTOR and dRictor have a shared positive role in the phosphorylation of the hydrophobic motif site of dAkt/dPKB.
      Title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by transcription factor localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein localization to nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC2 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rapamycin-insensitive companion of Tor
    Names
    CG8002-PA
    CG8002-PB
    CG8002-PC
    dRictor
    rictor
    rictor-PA
    rictor-PB
    rictor-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19252111..19261240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298503.1 → NP_001285432.1  rapamycin-insensitive companion of Tor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285432.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU91, X2JL73
      Conserved Domains (4) summary
      pfam14663
      Location:785 → 888
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:63 → 440
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:567 → 778
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:957 → 1027
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    2. NM_133143.2 → NP_573371.1  rapamycin-insensitive companion of Tor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU91, Q9VWJ6
      Related
      FBpp0074458
      Conserved Domains (4) summary
      pfam14663
      Location:805 → 908
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:63 → 440
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:583 → 798
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:977 → 1047
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    3. NM_001298504.1 → NP_001285433.1  rapamycin-insensitive companion of Tor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU91, X2JFR5
      Conserved Domains (4) summary
      pfam14663
      Location:793 → 896
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:51 → 428
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14666
      Location:571 → 786
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:965 → 1035
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU91 Q7YU91
    Q9VWJ6 Q9VWJ6
    X2JFR5 X2JFR5
    X2JL73 X2JL73

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