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    glpD aerobic glycerol 3-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947934, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glpD
    Official Full Name
    aerobic glycerol 3-phosphate dehydrogenase
    Primary source
    ECOCYC:EG10394
    Locus tag
    b3426
    See related
    ASAP:ABE-0011191
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3412; glyD
    Summary
    LpxB and GlpD associate in vitro. [More information is available at EcoGene: EG10394]. The aerobic glycerol 3-phosphate dehydrogenase (GlpD) is a homodimeric enzyme associated with the cytoplasmic membrane through binding to negatively-charged phopholipids . [More information is available at EcoCyc: EG10394].
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    Genomic context

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    Sequence:
    NC_000913.3 (3562013..3563518)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene rhomboid protease GlpG Neighboring gene thiosulfate sulfurtransferase GlpE Neighboring gene putative uncharacterized protein YzgL Neighboring gene glycogen phosphorylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures of the promoter and operator of the glpD gene encoding aerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia coli K-12. Ye SZ, et al. J Bacteriol, 1988 Sep. PMID 3045087, Free PMC Article
    2. Growth stasis by accumulated L-alpha-glycerophosphate in Escherichia coli. Cozzarelli NR, et al. J Bacteriol, 1965 Nov. PMID 5321485, Free PMC Article
    3. Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of Escherichia coli. Schryvers A, et al. J Biol Chem, 1978 Feb 10. PMID 340460
    4. Peptergents: peptide detergents that improve stability and functionality of a membrane protein, glycerol-3-phosphate dehydrogenase. Yeh JI, et al. Biochemistry, 2005 Dec 27. PMID 16363804
    5. Aerobic sn-glycerol-3-phosphate dehydrogenase from Escherichia coli binds to the cytoplasmic membrane through an amphipathic alpha-helix. Walz AC, et al. Biochem J, 2002 Jul 15. PMID 11955283, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Association of lipid A disaccharide synthase with aerobic glycerol-3-phosphate dehydrogenase in extracts of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in anaerobic respiration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organophosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycerol-3-phosphate dehydrogenase (FAD) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aerobic glycerol 3-phosphate dehydrogenase
    NP_417884.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3562013..3563518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417884.1 aerobic glycerol 3-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417884.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JBK2
      Conserved Domains (1) summary
      PRK12266
      Location:27 → 501
      glpD; glycerol-3-phosphate dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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