DDL1 putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DDL1
Official Full Name: putative carboxylic ester hydrolase
Primary source: SGD:S000005548
Locus tag: YOR022C
See related: AllianceGenome:SGD:S000005548; FungiDB:YOR022C; VEuPathDB:YOR022C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phospholipase activity. Involved in cardiolipin metabolic process and phosphatidylethanolamine metabolic process. Located in mitochondrial matrix. Used to study hereditary spastic paraplegia 28 and hereditary spastic paraplegia 54. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 28 and hereditary spastic paraplegia 54. Orthologous to several human genes including DDHD2 (DDHD domain containing 2) and SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DDL1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (373710..375857, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study reveals that the misregulation of DDL1 by Aft1/2 transcription factors alters CL metabolism and causes mitochondrial dysfunction in the cells.
Title: Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiolipin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative carboxylic ester hydrolase

NP_014665.1

DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

373710..375857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183441.1 → NP_014665.1 TPA: putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014665.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W289, Q12204

UniProtKB/TrEMBL

A6ZNM7

Conserved Domains (1) summary

pfam02862
Location:522 → 699

DDHD; DDHD domain