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    Wdr5 WD repeat domain 5 [ Mus musculus (house mouse) ]

    Gene ID: 140858, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr5provided by MGI
    Official Full Name
    WD repeat domain 5provided by MGI
    Primary source
    MGI:MGI:2155884
    See related
    Ensembl:ENSMUSG00000026917 AllianceGenome:MGI:2155884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Big; Big-3; 2410008O07Rik
    Summary
    Enables histone H3K4 methyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within peptidyl-lysine methylation; positive regulation of gluconeogenesis; and skeletal system development. Located in nucleus. Part of ATAC complex. Is expressed in several structures, including cerebral cortex; colon; genitourinary system; hemolymphoid system gland; and vault of skull. Orthologous to human WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 20.0), limb E14.5 (RPKM 18.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Wdr5 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27405159..27426547)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27515147..27536535)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bromodomain containing 3 Neighboring gene makorin, ring finger protein, 1 pseudogene Neighboring gene predicted gene, 54108 Neighboring gene STARR-seq mESC enhancer starr_04005 Neighboring gene STARR-seq mESC enhancer starr_04007 Neighboring gene STARR-positive B cell enhancer mm9_chr2:27395293-27395594 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27395737-27395846 Neighboring gene STARR-seq mESC enhancer starr_04008 Neighboring gene predicted gene, 25541 Neighboring gene predicted gene 13421

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of gluconeogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-lysine methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gluconeogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within skeletal system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Set1C/COMPASS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of histone methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 5
    Names
    BMP2-induced 3-kb gene protein
    WD repeat-containing protein BIG-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080848.2NP_543124.1  WD repeat-containing protein 5

      See identical proteins and their annotated locations for NP_543124.1

      Status: VALIDATED

      Source sequence(s)
      AA023626, AF416510
      Consensus CDS
      CCDS15829.1
      UniProtKB/Swiss-Prot
      P61965, Q922C9
      UniProtKB/TrEMBL
      Q3UNQ3
      Related
      ENSMUSP00000109585.4, ENSMUST00000113952.10
      Conserved Domains (2) summary
      cd00200
      Location:37331
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4885
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      27405159..27426547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497672.4XP_006497735.1  WD repeat-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006497735.1

      UniProtKB/Swiss-Prot
      P61965, Q922C9
      UniProtKB/TrEMBL
      Q3UNQ3
      Conserved Domains (2) summary
      cd00200
      Location:37331
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4885
      7WD40; WD40 repeat [structural motif]