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    Ly6g2 lymphocyte antigen 6 family member G2 [ Mus musculus (house mouse) ]

    Gene ID: 223631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ly6g2provided by MGI
    Official Full Name
    lymphocyte antigen 6 family member G2provided by MGI
    Primary source
    MGI:MGI:2385015
    See related
    Ensembl:ENSMUSG00000047728 AllianceGenome:MGI:2385015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in midgut; renal calyx; and renal pelvis. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 47.5), large intestine adult (RPKM 18.3) and 6 other tissues See more
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    Genomic context

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    See Ly6g2 in Genome Data Viewer
    Location:
    15 D3; 15 34.29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75088227..75094510)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75216351..75222661)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G Neighboring gene predicted gene 28117 Neighboring gene predicted pseudogene 10238 Neighboring gene lymphocyte antigen 6 family member F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC29251

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte antigen 6 complex, locus G2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371105.1 → NP_001358034.1  lymphocyte antigen 6 complex, locus G2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      Consensus CDS
      CCDS88780.1
      UniProtKB/TrEMBL
      A0A087WQT1
      Related
      ENSMUSP00000140330.2, ENSMUST00000185307.7
      Conserved Domains (1) summary
      cd00117
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    2. NM_001371106.1 → NP_001358035.1  lymphocyte antigen 6 complex, locus G2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      Consensus CDS
      CCDS88780.1
      UniProtKB/TrEMBL
      A0A087WQT1
      Conserved Domains (1) summary
      cd00117
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    3. NM_001371107.1 → NP_001358036.1  lymphocyte antigen 6 complex, locus G2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      Consensus CDS
      CCDS88780.1
      UniProtKB/TrEMBL
      A0A087WQT1
      Related
      ENSMUSP00000155184.2, ENSMUST00000229521.2
      Conserved Domains (1) summary
      cd00117
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    4. NM_001371108.1 → NP_001358037.1  lymphocyte antigen 6 complex, locus G2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      Consensus CDS
      CCDS88779.1
      UniProtKB/TrEMBL
      Q8R155
      Related
      ENSMUSP00000053396.7, ENSMUST00000055719.8
      Conserved Domains (1) summary
      cd00117
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    5. NM_001416438.1 → NP_001403367.1  lymphocyte antigen 6 complex, locus G2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC116498
      UniProtKB/TrEMBL
      Q8R155

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75088227..75094510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248479.1 → XP_030104339.1  lymphocyte antigen 6 complex, locus G2 isoform X1

      UniProtKB/TrEMBL
      A0A087WQT1
      Conserved Domains (1) summary
      cd00117
      Location:27 → 107
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_146058.1: Suppressed sequence

      Description
      NM_146058.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials