Gimap3 GTPase, IMAP family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gimap3provided by MGI
Official Full Name: GTPase, IMAP family member 3provided by MGI
Primary source: MGI:MGI:1932723
See related: Ensembl:ENSMUSG00000039264 AllianceGenome:MGI:1932723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ian4; Gimap5; 2010110D23Rik
Summary: This gene encodes a mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The expression of this gene is induced in BCR/ABL-expressing cells. The encoded protein lacks an N-terminal mitochondrial signal sequence. Experimental studies showed that mitochondrial localization relies on the C-terminal transmembrane domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1 [provided by RefSeq, Jul 2008]
Expression: Biased expression in spleen adult (RPKM 59.8), mammary gland adult (RPKM 20.6) and 4 other tissues See more
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Genomic context

Location:: 6 B2.3; 6 23.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (48741398..48747785, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (48764464..48770851, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

quantitative changes in expression of Gimap3 and the paralogue Gimap5 affect mtDNA segregation in hematopoietic tissues. Gimap3 localizes to the endoplasmic reticulum and not mitochondria.
Title: Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.
The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5.
Title: Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.
Data shsow that Gimap3 is important for T cell development and survival, suggesting that leukocyte survival may be a key factor in the genetic regulation of mtDNA sequence variants and in modulating human mitochondrial diseases.
Title: Gimap3 regulates tissue-specific mitochondrial DNA segregation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: GTPase IMAP family member 3

Names: IAN-4; immune associated nucleotide 4; immunity-associated nucleotide 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.