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    MARK2 microtubule affinity regulating kinase 2 [ Homo sapiens (human) ]

    Gene ID: 2011, updated on 5-Jan-2025

    Summary

    Official Symbol
    MARK2provided by HGNC
    Official Full Name
    microtubule affinity regulating kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:3332
    See related
    Ensembl:ENSG00000072518 MIM:600526; AllianceGenome:HGNC:3332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMK1; EMK-1; PAR-1; Par1b; Par-1b
    Summary
    This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
    Expression
    Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MARK2 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63839110..63911020)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63828449..63900374)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63606582..63678492)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3446 Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene ReSE screen-validated silencer GRCh37_chr11:63598793-63599010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63599819-63600638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63605268-63606256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3447 Neighboring gene ATP synthase membrane subunit g pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4877 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63642729-63643230 Neighboring gene RNA, U6 small nuclear 1306, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4878 Neighboring gene tRNA-Arg (anticodon CCT) 9-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63670286-63671098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63674933-63675606 Neighboring gene Sharpr-MPRA regulatory region 844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63682139-63683091 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63683713-63684376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63687688-63688350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63688351-63689011 Neighboring gene REST corepressor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63705477-63705977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4879 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:63706395-63706580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63712515-63713444 Neighboring gene N-alpha-acetyltransferase 40, NatD catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (154 hits/1322 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC99619

    Gene Ontology Provided by GOA

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables DNA-dependent protein kinase activity  
    enables RNA binding PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables cadherin binding PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables lipid binding  
    enables magnesium ion binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activator activity PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables tau protein binding PubMed 
    enables tau protein binding PubMed 
    enables tau-protein kinase activity  
    enables tau-protein kinase activity PubMed 
    enables tau-protein kinase activity PubMed 
    enables tau-protein kinase activity PubMed 
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in autophagy of mitochondrion PubMed 
    involved_in axon development PubMed 
    involved_in chromatin remodeling  
    involved_in establishment of cell polarity PubMed 
    involved_in establishment of cell polarity PubMed 
    involved_in establishment or maintenance of cell polarity regulating cell shape PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity PubMed 
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in microtubule cytoskeleton organization  
    involved_in mitochondrion localization PubMed 
    involved_in neuron migration  
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in protein autophosphorylation  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of axonogenesis PubMed 
    involved_in regulation of cytoskeleton organization  
    involved_in regulation of microtubule binding PubMed 
    involved_in regulation of microtubule cytoskeleton organization PubMed 
    Component Evidence Code Pubs
    located_in actin filament PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in dendrite PubMed 
    located_in lateral plasma membrane PubMed 
    located_in membrane PubMed 
    located_in microtubule bundle PubMed 
    located_in mitochondrion PubMed 
    located_in nucleoplasm  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase MARK2
    Names
    ELKL motif kinase 1
    MAP/microtubule affinity-regulating kinase 2
    PAR1 homolog b
    Ser/Thr protein kinase PAR-1B
    serine/threonine protein kinase EMK
    testicular tissue protein Li 117
    NP_001034558.2
    NP_001156768.1
    NP_001156769.1
    NP_004945.4
    NP_059672.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029771.1 RefSeqGene

      Range
      5183..77093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039469.3 → NP_001034558.2  serine/threonine-protein kinase MARK2 isoform d

      See identical proteins and their annotated locations for NP_001034558.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AB188493, AK225766, AP003780, BC008771, BM719402
      Consensus CDS
      CCDS53649.1
      UniProtKB/Swiss-Prot
      Q15449, Q15524, Q5XGA3, Q68A18, Q7KZI7, Q96HB3, Q96RG0
      UniProtKB/TrEMBL
      A8K2S4
      Related
      ENSP00000385751.2, ENST00000402010.8
      Conserved Domains (3) summary
      cd12201
      Location:689 → 787
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. NM_001163296.2 → NP_001156768.1  serine/threonine-protein kinase MARK2 isoform e

      See identical proteins and their annotated locations for NP_001156768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 4. The resulting isoform (e) lacks two internal segments, compared to isoform d.
      Source sequence(s)
      AB188493, AK225766, AP003780, BM719402
      Consensus CDS
      CCDS53650.1
      UniProtKB/TrEMBL
      A0A0A0MRU9, A0A140VJP1
      Related
      ENSP00000355091.5, ENST00000361128.9
      Conserved Domains (3) summary
      cd12201
      Location:620 → 718
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. NM_001163297.2 → NP_001156769.1  serine/threonine-protein kinase MARK2 isoform f

      See identical proteins and their annotated locations for NP_001156769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (f) lacks two internal segments and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AK225766, AP003780, BM719402
      Consensus CDS
      CCDS53651.1
      UniProtKB/TrEMBL
      A0A0A0MRU9
      Related
      ENSP00000294247.9, ENST00000350490.11
      Conserved Domains (3) summary
      cd12201
      Location:610 → 708
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. NM_004954.5 → NP_004945.4  serine/threonine-protein kinase MARK2 isoform c

      See identical proteins and their annotated locations for NP_004945.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (c) lacks two internal segments and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AK225766, AP003780, BC084540, BM719402
      Consensus CDS
      CCDS8051.2
      UniProtKB/TrEMBL
      A0A0A0MRU9
      Related
      ENSP00000425765.1, ENST00000508192.5
      Conserved Domains (3) summary
      cd12201
      Location:625 → 723
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. NM_017490.4 → NP_059672.2  serine/threonine-protein kinase MARK2 isoform a

      See identical proteins and their annotated locations for NP_059672.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, lacks an in-frame exon, and uses an alternate in-frame splice site, compared to variant 4. The resulting isoform (a) has a shorter N-terminus and lacks an internal segment and 1 internal residue, compared to isoform d.
      Source sequence(s)
      AK290339, AP003780, BM719402, BT007342, DA855402
      Consensus CDS
      CCDS41665.1
      UniProtKB/TrEMBL
      A8K2S4
      Related
      ENSP00000423974.2, ENST00000509502.6
      Conserved Domains (3) summary
      cd12201
      Location:646 → 744
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      cd14406
      Location:289 → 330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19 → 271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63839110..63911020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63828449..63900374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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