Lpcat4 lysophosphatidylcholine acyltransferase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpcat4provided by MGI
Official Full Name: lysophosphatidylcholine acyltransferase 4provided by MGI
Primary source: MGI:MGI:2138993
See related: Ensembl:ENSMUSG00000027134 AllianceGenome:MGI:2138993
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aytl3; Agpat7; LPEAT2
Summary: Enables 1-acylglycerophosphocholine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human LPCAT4 (lysophosphatidylcholine acyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in stomach adult (RPKM 59.3), cortex adult (RPKM 45.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 56.96 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (112070186..112077456)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (112239841..112247111)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion.
Title: Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion.
Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2) incorporates DHA into phospholipids and has possible functions for fatty acid-induced cell death.
Title: Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2) incorporates DHA into phospholipids and has possible functions for fatty acid-induced cell death.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkylglycerophosphocholine O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-alkylglycerophosphocholine O-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipid acyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylcholine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophospholipid acyltransferase LPCAT4

Names: -acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); 1-AGP acyltransferase 7; 1-AGPAT 7; 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta); 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 1-alkenylglycerophosphoethanolamine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; acyltransferase-like 3; lysophosphatidylethanolamine acyltransferase 2; plasmalogen synthase

NP_997089.1

EC 2.3.1.121

EC 2.3.1.23

EC 2.3.1.67

EC 2.3.1.n6

EC 2.3.1.n7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207206.2 → NP_997089.1 lysophospholipid acyltransferase LPCAT4

See identical proteins and their annotated locations for NP_997089.1

Status: VALIDATED

Source sequence(s)

AL713853, BC068131

Consensus CDS

CCDS16548.1

UniProtKB/Swiss-Prot

Q66JP7, Q6NVG1

Related

ENSMUSP00000028554.4, ENSMUST00000028554.4

Conserved Domains (2) summary

cd07991
Location:109 → 306

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

COG0204
Location:109 → 295

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]