Lrrc38 leucine rich repeat containing 38 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc38provided by MGI
Official Full Name: leucine rich repeat containing 38provided by MGI
Primary source: MGI:MGI:2442845
See related: Ensembl:ENSMUSG00000028584 AllianceGenome:MGI:2442845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A230053A07Rik
Summary: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC38 (leucine rich repeat containing 38). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 1.6), mammary gland adult (RPKM 0.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E1; 4 77.55 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (143076242..143097602)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (143347076..143371032)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 38

Names: BK channel auxiliary gamma subunit LRRC38; BK channel auxilliary gamma subunit LRRC38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162983.1 → NP_001156455.1 leucine-rich repeat-containing protein 38 precursor

See identical proteins and their annotated locations for NP_001156455.1

Status: VALIDATED

Source sequence(s)

AK045936, AK160116, AL611982, BC129963

Consensus CDS

CCDS51351.1

UniProtKB/Swiss-Prot

A2A8J4, A2VDH3, Q3TVH8, Q8BR15

Related

ENSMUSP00000053597.3, ENSMUST00000052458.3

Conserved Domains (5) summary

smart00013
Location:31 → 62

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:49 → 190

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:42 → 64

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:133 → 191

LRR_8; Leucine rich repeat

cl15307
Location:190 → 244

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

143076242..143097602

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538855.5 → XP_006538918.1 leucine-rich repeat-containing protein 38 isoform X1

See identical proteins and their annotated locations for XP_006538918.1

Conserved Domains (3) summary

smart00013
Location:171 → 202

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:182 → 204

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:273 → 331

LRR_8; Leucine rich repeat