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    lec-12 Galectin;Galectin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lec-12
    Official Full Name
    Galectin;Galectin domain-containing protein
    Primary source
    WormBase:WBGene00017080
    Locus tag
    CELE_DC2.3
    See related
    AllianceGenome:WB:WBGene00017080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbohydrate binding activity and galactoside binding activity. Predicted to be located in membrane. Orthologous to human LGALS4 (galectin 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lec-12 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (204382..209755)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AT-rich interactive domain-containing protein arid-1 Neighboring gene Trafficking protein particle complex subunit Neighboring gene DeHydrogenases, Short chain Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DC2.3 gene in Caenorhabditis elegans encodes a galectin that recognizes the galactoseβ1→4fucose disaccharide unit. Nemoto-Sasaki Y, et al. Biol Pharm Bull, 2011. PMID 21963509
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Galectin;Galectin domain-containing protein
    NP_001023758.2
    • Partially confirmed by transcript evidence
    NP_001023759.2
    • Confirmed by transcript evidence
    NP_001300065.1
    • Partially confirmed by transcript evidence
    NP_001300066.1
    • Confirmed by transcript evidence
    NP_001300067.1
    • Confirmed by transcript evidence
    NP_001300068.1
    • Confirmed by transcript evidence
    NP_001300069.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      204382..209755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028588.6 → NP_001023759.2  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023759.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ZR27
      Conserved Domains (2) summary
      smart00908
      Location:208 → 337
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:21 → 167
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    2. NM_001028587.4 → NP_001023758.2  Galectin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023758.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZJ9
      Conserved Domains (1) summary
      cd00070
      Location:21 → 167
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    3. NM_001313137.3 → NP_001300066.1  Galectin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUS0
      Conserved Domains (2) summary
      smart00908
      Location:168 → 297
      Gal-bind_lectin; Galactoside-binding lectin
      cd00070
      Location:8 → 127
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    4. NM_001313136.3 → NP_001300065.1  Galectin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASC7
      Conserved Domains (1) summary
      cd00070
      Location:8 → 127
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    5. NM_001313139.3 → NP_001300068.1  Galectin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVE8
      Conserved Domains (2) summary
      smart00908
      Location:69 → 198
      Gal-bind_lectin; Galactoside-binding lectin
      cl00071
      Location:2 → 30
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    6. NM_001313138.1 → NP_001300067.1  Galectin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARW6
      Conserved Domains (1) summary
      cl00071
      Location:2 → 30
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

    7. NM_001313140.3 → NP_001300069.1  Galectin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXP2
      Conserved Domains (1) summary
      smart00908
      Location:11 → 90
      Gal-bind_lectin; Galactoside-binding lectin
    Nucleotide Protein
    Heading Accession and Version

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