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    trr-1 Transcription-associated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 174788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trr-1
    Official Full Name
    Transcription-associated protein 1
    Primary source
    WormBase:WBGene00007028
    Locus tag
    CELE_C47D12.1
    See related
    AllianceGenome:WB:WBGene00007028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of vulval development and positive regulation of growth rate. Located in condensed chromosome and nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and germ line. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    22
    Sequence:
    Chromosome: II; NC_003280.10 (11661569..11675927, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neprilysin-1 Neighboring gene ncRNA Neighboring gene Dymeclin Neighboring gene Sideroflexin-2;Sidoreflexin Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary change within a bipotential switch shaped the sperm/oocyte decision in hermaphroditic nematodes. Guo Y, et al. PLoS Genet, 2013. PMID 24098152, Free PMC Article
    2. The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors. Ikeda T, et al. EMBO Rep, 2017 Oct. PMID 28794203, Free PMC Article
    3. An RNAi screen for conserved kinases that enhance microRNA activity after dauer in Caenorhabditis elegans. Roka Pun H, et al. G3 (Bethesda), 2024 Mar 6. PMID 38226857, Free PMC Article
    4. Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. Fisher K, et al. Dev Biol, 2010 May 1. PMID 20188723
    5. lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans. Bender AM, et al. Dev Biol, 2007 Feb 15. PMID 17070797, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription-associated protein 1
    NP_001364592.1
    • Confirmed by transcript evidence
    NP_001364646.1
    • Confirmed by transcript evidence
    NP_001364647.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11661569..11675927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377878.3 → NP_001364646.1  Transcription-associated protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEV2, Q5CZ43, Q6A4L2
      Conserved Domains (1) summary
      cd05163
      Location:3678 → 4014
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein

    2. NM_001377879.1 → NP_001364592.1  Transcription-associated protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEV2, Q5CZ43, Q6A4L2
      Conserved Domains (1) summary
      cd05163
      Location:3678 → 4017
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein

    3. NM_001377877.2 → NP_001364647.1  Transcription-associated protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEV2, Q5CZ43, Q6A4L2
      Conserved Domains (1) summary
      cd05163
      Location:3667 → 4006
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    Nucleotide Protein
    Heading Accession and Version

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