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    • Showing Current items.

    nuo-2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 172363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nuo-2
    Official Full Name
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
    Primary source
    WormBase:WBGene00020417
    Locus tag
    CELE_T10E9.7
    See related
    AllianceGenome:WB:WBGene00020417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in determination of adult lifespan. Located in mitochondrion. Is expressed in reproductive system and seam cell. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 8. Orthologous to human NDUFS3 (NADH:ubiquinone oxidoreductase core subunit S3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nuo-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (6530131..6531963, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein of unknown function DX domain-containing protein Neighboring gene Receptor expression-enhancing protein Neighboring gene K Homology domain-containing protein Neighboring gene DOMON domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants. Grad LI, et al. Biochim Biophys Acta, 2006 Feb. PMID 16443191
    2. Rates of behavior and aging specified by mitochondrial function during development. Dillin A, et al. Science, 2002 Dec 20. PMID 12471266
    3. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. Rea SL, et al. PLoS Biol, 2007 Oct 2. PMID 17914900, Free PMC Article
    4. The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging. Angeli S, et al. Elife, 2021 Sep 1. PMID 34467850, Free PMC Article
    5. Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Ventura N, et al. Biotechnol J, 2007 May. PMID 17443764

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
    NP_871796.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6530131..6531963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181996.6 → NP_871796.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NC2
      Conserved Domains (1) summary
      PRK06074
      Location:53 → 237
      PRK06074; NADH dehydrogenase subunit C; Provisional
    Nucleotide Protein
    Heading Accession and Version

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