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    ZC3H7A zinc finger CCCH-type containing 7A [ Homo sapiens (human) ]

    Gene ID: 29066, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZC3H7Aprovided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 7Aprovided by HGNC
    Primary source
    HGNC:HGNC:30959
    See related
    Ensembl:ENSG00000122299 MIM:619819; AllianceGenome:HGNC:30959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZC3H7; HSPC055; ZC3HDC7
    Summary
    Enables miRNA binding activity. Involved in miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZC3H7A in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11750597..11797258, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11786640..11833292, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11844453..11891114, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene stannin Neighboring gene thioredoxin domain containing 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10456 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11836693-11837215 Neighboring gene TXNDC11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene breast cancer anti-estrogen resistance 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene ribosomal L1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of new high affinity targets for Roquin based on structural conservation. Braun J, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295819, Free PMC Article
    2. Common variants at ten loci influence QT interval duration in the QTGEN Study. Newton-Cheh C, et al. Nat Genet, 2009 Apr. PMID 19305408, Free PMC Article
    3. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. MacLeod G, et al. Cell Rep, 2019 Apr 16. PMID 30995489
    4. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B. Hunter MR, et al. J Mol Biol, 2018 Jul 6. PMID 29778605, Free PMC Article
    5. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Schmidt N, et al. Cell, 2023 Oct 26. PMID 37794589, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants at ten loci influence QT interval duration in the QTGEN Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10027, FLJ20318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 7A
    Names
    zinc finger CCCH-type domain containing 7
    zinc-finger protein AY163807

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014153.4 → NP_054872.2  zinc finger CCCH domain-containing protein 7A

      See identical proteins and their annotated locations for NP_054872.2

      Status: VALIDATED

      Source sequence(s)
      AY163807, BC046363, DA160892
      Consensus CDS
      CCDS10550.1
      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
      Related
      ENSP00000347999.4, ENST00000355758.9
      Conserved Domains (5) summary
      smart00356
      Location:906 → 926
      ZnF_C3H1; zinc finger
      sd00020
      Location:859 → 881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857 → 882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13414
      Location:44 → 119
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11750597..11797258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522463.3 → XP_011520765.1  zinc finger CCCH domain-containing protein 7A isoform X1

      See identical proteins and their annotated locations for XP_011520765.1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
      Conserved Domains (5) summary
      smart00356
      Location:906 → 926
      ZnF_C3H1; zinc finger
      sd00020
      Location:859 → 881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857 → 882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13414
      Location:44 → 119
      TPR_11; TPR repeat

    2. XM_047433996.1 → XP_047289952.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9

    3. XM_006720877.3 → XP_006720940.1  zinc finger CCCH domain-containing protein 7A isoform X1

      See identical proteins and their annotated locations for XP_006720940.1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9
      Conserved Domains (5) summary
      smart00356
      Location:906 → 926
      ZnF_C3H1; zinc finger
      sd00020
      Location:859 → 881
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:857 → 882
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13414
      Location:44 → 119
      TPR_11; TPR repeat

    4. XM_017023174.2 → XP_016878663.1  zinc finger CCCH domain-containing protein 7A isoform X2

    5. XM_011522464.3 → XP_011520766.1  zinc finger CCCH domain-containing protein 7A isoform X4

      Conserved Domains (3) summary
      smart00356
      Location:667 → 687
      ZnF_C3H1; zinc finger
      sd00020
      Location:620 → 642
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:618 → 643
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    6. XM_047433998.1 → XP_047289954.1  zinc finger CCCH domain-containing protein 7A isoform X5

    7. XM_047433997.1 → XP_047289953.1  zinc finger CCCH domain-containing protein 7A isoform X3

      UniProtKB/TrEMBL
      I3L2K5
      Related
      ENSP00000459747.1, ENST00000571198.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11786640..11833292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380153.1 → XP_054236128.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9

    2. XM_054380155.1 → XP_054236130.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9

    3. XM_054380154.1 → XP_054236129.1  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/Swiss-Prot
      D3DUG5, Q8IWR0, Q9NPE9

    4. XM_054380156.1 → XP_054236131.1  zinc finger CCCH domain-containing protein 7A isoform X2

    5. XM_054380158.1 → XP_054236133.1  zinc finger CCCH domain-containing protein 7A isoform X4

    6. XM_054380159.1 → XP_054236134.1  zinc finger CCCH domain-containing protein 7A isoform X5

    7. XM_054380157.1 → XP_054236132.1  zinc finger CCCH domain-containing protein 7A isoform X3

      UniProtKB/TrEMBL
      I3L2K5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWR0.1 GenPept UniProtKB/Swiss-Prot:Q8IWR0

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