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    DOT6 Dot6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856822, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DOT6
    Official Full Name
    Dot6p
    Primary source
    SGD:S000000890
    Locus tag
    YER088C
    See related
    AllianceGenome:SGD:S000000890; FungiDB:YER088C; VEuPathDB:YER088C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PBF2
    Summary
    Enables sequence-specific DNA binding activity. Involved in rDNA heterochromatin formation; regulation of transcription by RNA polymerase II; and subtelomeric heterochromatin formation. Located in cytoplasm and nucleus. Part of Rpd3L-Expanded complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DOT6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (333176..335188, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative proline--tRNA ligase AIM10 Neighboring gene Arf family guanine nucleotide exchange factor SBH1 Neighboring gene type 2C protein phosphatase PTC2 Neighboring gene anthranilate synthase TRP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microarray profiling of phage-display selections for rapid mapping of transcription factor-DNA interactions. Freckleton G, et al. PLoS Genet, 2009 Apr. PMID 19360118, Free PMC Article
    2. Decoupling Yeast Cell Division and Stress Defense Implicates mRNA Repression in Translational Reallocation during Stress. Ho YH, et al. Curr Biol, 2018 Aug 20. PMID 30078561, Free PMC Article
    3. Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6. Lippman SI, et al. Proc Natl Acad Sci U S A, 2009 Nov 24. PMID 19901341, Free PMC Article
    4. A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Lee MV, et al. Mol Syst Biol, 2011 Jul 19. PMID 21772262, Free PMC Article
    5. Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast. Hickman MJ, et al. Mol Biol Cell, 2011 Nov. PMID 21900497, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results establish Dot6/Tod6 as a direct link between nutrient availability, Ribi gene regulation, and growth control through protein kinase A and TORC1.
      Title: Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex HDA PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dot6p
    NP_011012.3
    • Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      333176..335188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178979.3 → NP_011012.3  TPA: Dot6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011012.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLZ5, P40059
      UniProtKB/TrEMBL
      G2WCX9
      Conserved Domains (1) summary
      pfam13921
      Location:75 → 125
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40059.1

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