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    NRM1 Nrm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NRM1
    Official Full Name
    Nrm1p
    Primary source
    SGD:S000005292
    Locus tag
    YNR009W
    See related
    AllianceGenome:SGD:S000005292; FungiDB:YNR009W; VEuPathDB:YNR009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor binding activity. Involved in G1/S transition of mitotic cell cycle and negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of MBF transcription complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NRM1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (642690..643439)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Atg3p Neighboring gene phospholipid:diacylglycerol acyltransferase Neighboring gene Cse2p Neighboring gene DEAH-box RNA-dependent ATPase PRP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1. Travesa A, et al. EMBO J, 2012 Apr 4. PMID 22333915, Free PMC Article
    2. Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint. Dmowski M, et al. PLoS Genet, 2017 Jan. PMID 28107343, Free PMC Article
    3. Binding specificity of the G1/S transcriptional regulators in budding yeast. Harris MR, et al. PLoS One, 2013. PMID 23593391, Free PMC Article
    4. Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6. Travesa A, et al. Mol Cell Biol, 2013 Apr. PMID 23382076, Free PMC Article
    5. Role of a Candida albicans Nrm1/Whi5 homologue in cell cycle gene expression and DNA replication stress response. Ofir A, et al. Mol Microbiol, 2012 May. PMID 22463761, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study describes a protein motif, the GTB motif (for G1/S transcription factor binding), in Nrm1 and Whi5 that is required to bind to the transcription factors
      Title: Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6.
    2. It was shown that genotoxic stress during S phase specifically induces MBF-regulated genes via direct phosphorylation of Nrm1 by Rad53, the effector checkpoint kinase.
      Title: DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1.
    3. APC(Cdh1) targeted Nrm1 and Yhp1 for degradation in early G1 phase
      Title: Anaphase promoting complex-dependent degradation of transcriptional repressors Nrm1 and Yhp1 in Saccharomyces cerevisiae.
    4. A negative feedback loop involving Nrm1 bound to MBF leads to transcriptional repression as cells exit G1 phase.
      Title: Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MBF transcription complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nrm1p
    NP_014406.1
    • Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      642690..643439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183186.1 → NP_014406.1  TPA: Nrm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZS83, D6W1I4, P53718
      UniProtKB/TrEMBL
      B3LPN1, B5VR40, C7GLP6, C8ZFN6, G2WL66, N1NXQ5
      Conserved Domains (1) summary
      pfam08528
      Location:103 → 127
      Whi5; Whi5 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53718.1

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