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    Cstb cystatin B [ Mus musculus (house mouse) ]

    Gene ID: 13014, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cstbprovided by MGI
    Official Full Name
    cystatin Bprovided by MGI
    Primary source
    MGI:MGI:109514
    See related
    Ensembl:ENSMUSG00000005054 AllianceGenome:MGI:109514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stfb
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Acts upstream of or within adult locomotory behavior. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Unverricht-Lundborg syndrome. Human ortholog(s) of this gene implicated in Unverricht-Lundborg syndrome and progressive myoclonus epilepsy 1A. Orthologous to human CSTB (cystatin B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in placenta adult (RPKM 262.8), bladder adult (RPKM 67.0) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Cstb in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78261504..78263456)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78425670..78427622)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10623 Neighboring gene LSM7 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:77862123-77862306 Neighboring gene ribosomal RNA processing 1 Neighboring gene microRNA 6907 Neighboring gene microRNA 6410 Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase Neighboring gene microRNA 6908

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in extracellular space  
    located_in extracellular space  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007793.3NP_031819.1  cystatin-B

      See identical proteins and their annotated locations for NP_031819.1

      Status: VALIDATED

      Source sequence(s)
      BC056170, BY091749
      Consensus CDS
      CCDS23964.1
      UniProtKB/Swiss-Prot
      Q3UAW2, Q62426
      Related
      ENSMUSP00000005185.7, ENSMUST00000005185.8
      Conserved Domains (1) summary
      pfam00031
      Location:492
      Cystatin; Cystatin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      78261504..78263456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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