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    cbrA two-component sensor CbrA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881602, updated on 24-Aug-2024

    Summary

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    Gene symbol
    cbrA
    Gene description
    two-component sensor CbrA
    Locus tag
    PA4725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5304011..5306962)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene suppressor protein DksA Neighboring gene glutamyl-Q tRNA(Asp) synthetase Neighboring gene hypothetical protein Neighboring gene two-component response regulator CbrB Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model. Yeung AT, et al. Infect Immun, 2014 Mar. PMID 24379284, Free PMC Article
    2. Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2. Sivakumar R, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34530138
    3. The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa. Yeung AT, et al. J Bacteriol, 2011 Feb. PMID 21169488, Free PMC Article
    4. The CbrA-CbrB two-component regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa. Nishijyo T, et al. Mol Microbiol, 2001 May. PMID 11401699
    5. Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa. Li W, et al. J Bacteriol, 2007 Aug. PMID 17545289, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2.
      Title: Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2.
    2. In summary, this study supports the notion that CbrAB and NtrBC form a network to control the C/N balance in P. aeruginosa.
      Title: Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables phosphorelay sensor kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    two-component sensor CbrA
    NP_253413.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5304011..5306962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253413.1 two-component sensor CbrA [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253413.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XCM7, Q9HV74
      Conserved Domains (2) summary
      COG0591
      Location:1 → 501
      PutP; Na+/proline symporter [Amino acid transport and metabolism]
      PRK11360
      Location:622 → 978
      PRK11360; two-component system sensor histidine kinase AtoS
    Nucleotide Protein
    Heading Accession and Version

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