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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_012518.2 RefSeqGene
- Range
-
5296..94983
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001136025.5 → NP_001129497.1 plastin-3 isoform 1
See identical proteins and their annotated locations for NP_001129497.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
- Source sequence(s)
-
AA704125, BC039049, BM979335, DC357886
- Consensus CDS
-
CCDS14568.1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
- Related
- ENSP00000445339.2, ENST00000539310.5
- Conserved Domains (5) summary
-
- cd00051
Location:16 → 82
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd21292
Location:101 → 245
- CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
- cd21328
Location:254 → 375
- CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
- cd21331
Location:377 → 510
- CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
- cd21334
Location:519 → 630
- CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
-
NM_001172335.3 → NP_001165806.1 plastin-3 isoform 2
See identical proteins and their annotated locations for NP_001165806.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains an alternate 5' non-coding exon, and uses an alternate in-frame donor splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter lacking an internal protein segment compared to isoform 1.
- Source sequence(s)
-
AA704125, AK298530, BC039049, BM979335
- UniProtKB/TrEMBL
- B4DPW9, Q53GY0
- Conserved Domains (2) summary
-
- COG5069
Location:79 → 596
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cl08302
Location:16 → 49
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
NM_001282337.2 → NP_001269266.1 plastin-3 isoform 3
See identical proteins and their annotated locations for NP_001269266.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) contains an exon in the 5' region (which results in the use of an alternate translation initiation codon) and another in-frame exon in the mid-coding region, which are not found in variant 1. The encoded isoform (3) is shorter with a distinct N-terminus, and contains a novel 9 aa protein segment compared to isoform 1.
- Source sequence(s)
-
AA704125, AK294509, BC039049, BM979335, DC320695, M34427
- Consensus CDS
-
CCDS78499.1
- UniProtKB/TrEMBL
-
Q53GY0
- Related
- ENSP00000289290.4, ENST00000289290.7
- Conserved Domains (2) summary
-
- COG5069
Location:45 → 610
- SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
- cd00051
Location:3 → 60
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
NM_001282338.2 → NP_001269267.1 plastin-3 isoform 4
See identical proteins and their annotated locations for NP_001269267.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) contains an alternate 5' non-coding exon and a novel exon in the 5' region that results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
- Source sequence(s)
-
AA704125, AK300575, BC039049, BM979335, DC357886
- UniProtKB/TrEMBL
-
Q53GY0
- Conserved Domains (4) summary
-
- smart00033
Location:356 → 459
- CH; Calponin homology domain
- cd00014
Location:79 → 194
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- pfam13499
Location:1 → 36
- EF-hand_7; EF-hand domain pair
- cl08302
Location:6 → 37
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
-
NM_005032.7 → NP_005023.2 plastin-3 isoform 1
See identical proteins and their annotated locations for NP_005023.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
- Source sequence(s)
-
AA704125, AK312391, BC039049, BM979335, DC320695, M34427
- Consensus CDS
-
CCDS14568.1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
- Related
- ENSP00000348163.3, ENST00000355899.8
- Conserved Domains (5) summary
-
- cd00051
Location:16 → 82
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd21292
Location:101 → 245
- CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
- cd21328
Location:254 → 375
- CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
- cd21331
Location:377 → 510
- CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
- cd21334
Location:519 → 630
- CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000023.11 Reference GRCh38.p14 Primary Assembly
- Range
-
115561174..115650861
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047442172.1 → XP_047298128.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_047442171.1 → XP_047298127.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_047442169.1 → XP_047298125.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_047442168.1 → XP_047298124.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_047442167.1 → XP_047298123.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_047442170.1 → XP_047298126.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
Alternate T2T-CHM13v2.0
Genomic
-
NC_060947.1 Alternate T2T-CHM13v2.0
- Range
-
113969539..114059207
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054327219.1 → XP_054183194.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_054327218.1 → XP_054183193.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_054327216.1 → XP_054183191.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_054327215.1 → XP_054183190.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_054327214.1 → XP_054183189.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0
-
XM_054327217.1 → XP_054183192.1 plastin-3 isoform X1
- UniProtKB/Swiss-Prot
- A8K579, B1AQ09, B4DGB4, B7Z6M1, P13797, Q86YI6
- UniProtKB/TrEMBL
-
Q53GY0