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    RPL10 ribosomal protein L10 [ Homo sapiens (human) ]

    Gene ID: 6134, updated on 27-Nov-2024

    Summary

    Official Symbol
    RPL10provided by HGNC
    Official Full Name
    ribosomal protein L10provided by HGNC
    Primary source
    HGNC:HGNC:10298
    See related
    Ensembl:ENSG00000147403 MIM:312173; AllianceGenome:HGNC:10298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QM; L10; NOV; uL16; AUTSX5; DXS648; MRXS35; DXS648E
    Summary
    This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 795.4), lymph node (RPKM 396.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPL10 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154398065..154402339)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152634585..152638859)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153626406..153630680)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Xq28 proximal FLNA-EMD recombination region Neighboring gene filamin A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153596747-153597274 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153597275-153597800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21087 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153599383-153599908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153599914-153600555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153608033-153608612 Neighboring gene Xq28 distal FLNA-EMD recombination region Neighboring gene emerin Neighboring gene uncharacterized LOC124905228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21100 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153626083-153626628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30060 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153627173-153627718 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153627719-153628262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153628263-153628808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153628809-153629352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30061 Neighboring gene deoxyribonuclease 1 like 1 Neighboring gene small nucleolar RNA, H/ACA box 70 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21101 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153641748-153641921 Neighboring gene tafazzin, phospholipid-lysophospholipid transacylase Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153647927-153648428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153648429-153648928 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153656739-153657240 Neighboring gene ATP6AP1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Autism spectrum disorder
    MedGen: C1510586 GeneReviews: Not available
    not available
    Autism, susceptibility to, X-linked 5
    MedGen: C3275438 OMIM: 300847 GeneReviews: Not available
    not available
    Intellectual disability, X-linked, syndromic, 35
    MedGen: C4478383 OMIM: 300998 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-10-24)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-10-24)

    ClinGen Genome Curation Page

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L10 (RPL10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L10 (RPL10) at amino acid residues 53-54 and 56-57 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23544, FLJ27072, DKFZp686J1851

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein uL16
    Names
    60S ribosomal protein L10
    Wilms tumor-related protein
    laminin receptor homolog
    tumor suppressor QM
    NP_001243506.2
    NP_001243509.2
    NP_001290553.1
    NP_001290554.1
    NP_001290555.1
    NP_006004.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012890.2 RefSeqGene

      Range
      5149..9104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256577.2NP_001243506.2  large ribosomal subunit protein uL16 isoform b

      See identical proteins and their annotated locations for NP_001243506.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct, longer C-terminus than isoform a.
      Source sequence(s)
      AC245140, AK307511, BC003358, DA589764
      UniProtKB/TrEMBL
      A6QRI9
      Related
      ENSP00000395025.1, ENST00000458500.5
      Conserved Domains (1) summary
      cl00353
      Location:1110
      Ribosomal_L16_L10e; Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with ...
    2. NM_001256580.2NP_001243509.2  large ribosomal subunit protein uL16 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC245140, BC003358, BC071918, BM845289, DA589764
      UniProtKB/TrEMBL
      F8W7C6
      Conserved Domains (1) summary
      cl00353
      Location:1173
      Ribosomal_L16_L10e; Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with ...
    3. NM_001303624.2NP_001290553.1  large ribosomal subunit protein uL16 isoform a

      See identical proteins and their annotated locations for NP_001290553.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 encode the same isoform (a).
      Source sequence(s)
      AC245140, AK026568, BC003358
      Consensus CDS
      CCDS14746.1
      UniProtKB/Swiss-Prot
      A3KQT0, D3DWW6, P27635, Q16470, Q2HXT7, Q53FH7, Q6FGN8, Q8TDA5
      UniProtKB/TrEMBL
      X1WI28, X5D2T3
      Related
      ENSP00000341730.4, ENST00000344746.8
      Conserved Domains (1) summary
      PTZ00173
      Location:1209
      PTZ00173; 60S ribosomal protein L10; Provisional
    4. NM_001303625.1NP_001290554.1  large ribosomal subunit protein uL16 isoform a

      See identical proteins and their annotated locations for NP_001290554.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 encode the same isoform (a).
      Source sequence(s)
      AC245140, BC003358, BM761549, DA589764
      Consensus CDS
      CCDS14746.1
      UniProtKB/Swiss-Prot
      A3KQT0, D3DWW6, P27635, Q16470, Q2HXT7, Q53FH7, Q6FGN8, Q8TDA5
      UniProtKB/TrEMBL
      X1WI28, X5D2T3
      Related
      ENSP00000388600.1, ENST00000436473.5
      Conserved Domains (1) summary
      PTZ00173
      Location:1209
      PTZ00173; 60S ribosomal protein L10; Provisional
    5. NM_001303626.1NP_001290555.1  large ribosomal subunit protein uL16 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has a shorter 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) has a distinct, shorter C-terminus than isoform a.
      Source sequence(s)
      AC245140, BC003358, BC095425, CA776692
      UniProtKB/Swiss-Prot
      P27635
      Conserved Domains (1) summary
      cl00353
      Location:1110
      Ribosomal_L16_L10e; L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, ...
    6. NM_006013.5NP_006004.3  large ribosomal subunit protein uL16 isoform a

      See identical proteins and their annotated locations for NP_006004.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1, 4, and 5 encode the same isoform (a).
      Source sequence(s)
      AC245140, AK130582
      Consensus CDS
      CCDS14746.1
      UniProtKB/Swiss-Prot
      A3KQT0, D3DWW6, P27635, Q16470, Q2HXT7, Q53FH7, Q6FGN8, Q8TDA5
      UniProtKB/TrEMBL
      X1WI28, X5D2T3
      Related
      ENSP00000358832.2, ENST00000369817.7
      Conserved Domains (1) summary
      PTZ00173
      Location:1209
      PTZ00173; 60S ribosomal protein L10; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      154398065..154402339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      152634585..152638859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)