lam-3 Laminin subunit alpha lam-3 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: lam-3
Official Full Name: Laminin subunit alpha lam-3
Primary source: WormBase:WBGene00002248
Locus tag: CELE_T22A3.8
See related: AllianceGenome:WB:WBGene00002248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in animal organ morphogenesis; axonogenesis; and tissue development. Located in basement membrane. Is expressed in several structures, including excretory canal; pharyngeal-intestinal valve; pharynx; somatic nervous system; and spermatheca. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA1 (laminin subunit alpha 1) and LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See lam-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (10608466..10621435)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Laminin is required to orient epithelial polarity in the C. elegans pharynx.
Title: Laminin is required to orient epithelial polarity in the C. elegans pharynx.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

STS1-188 (e-PCR)
- UniSTS:241678

T22A3.8 (e-PCR)
- UniSTS:311634

C43H8.3 (e-PCR)
- UniSTS:319128

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Laminin subunit alpha lam-3

NP_492775.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10608466..10621435

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060374.5 → NP_492775.2 Laminin subunit alpha lam-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492775.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECE3

Conserved Domains (10) summary

smart00136
Location:42 → 294

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:988 → 1033

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:583 → 711

LamB; Laminin B domain

smart00282
Location:2285 → 2443

LamG; Laminin G domain

COG1842
Location:1864 → 2121

PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]

cd00055
Location:1646 → 1694

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2471 → 2622

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1086 → 1134

Laminin_EGF; Laminin EGF domain

pfam06009
Location:2157 → 2286

Laminin_II; Laminin Domain II

cl12013
Location:1848 → 2058

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature