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    cat-1 Major facilitator superfamily (MFS) profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cat-1
    Official Full Name
    Major facilitator superfamily (MFS) profile domain-containing protein
    Primary source
    WormBase:WBGene00000295
    Locus tag
    CELE_W01C8.6
    See related
    AllianceGenome:WB:WBGene00000295
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables dopamine:sodium symporter activity and serotonin:sodium:chloride symporter activity. Involved in dopamine metabolic process; feeding behavior; and monoamine transport. Located in synaptic vesicle. Is expressed in gonad; nervous system; and in male. Used to study amphetamine abuse and cocaine abuse. Human ortholog(s) of this gene implicated in Parkinson's disease; bipolar disorder; infantile parkinsonism-dystonia 2; schizophrenia; and type 1 diabetes mellitus. Orthologous to human SLC18A1 (solute carrier family 18 member A1) and SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cat-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (5705690..5710625, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene tRNA-Ser Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene Cytochrome P450 Neighboring gene Calcineurin-like phosphoesterase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic or Toxicant-Induced Disruption of Vesicular Monoamine Storage and Global Metabolic Profiling in Caenorhabditis elegans. Bradner JM, et al. Toxicol Sci, 2021 Apr 12. PMID 33538833, Free PMC Article
    2. State-dependency in C. elegans. Bettinger JC, et al. Genes Brain Behav, 2004 Oct. PMID 15344920
    3. Multimodal Stimulation in a Microfluidic Device Facilitates Studies of Interneurons in Sensory Integration in C. elegans. Cho Y, et al. Small, 2020 Mar. PMID 32003130, Free PMC Article
    4. β-Phenylethylamine requires the dopamine transporter to increase extracellular dopamine in Caenorhabditis elegans dopaminergic neurons. Hossain M, et al. Neurochem Int, 2014 Jul. PMID 24161617, Free PMC Article
    5. The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors. Duerr JS, et al. J Neurosci, 1999 Jan 1. PMID 9870940, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dopamine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serotonin:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin:sodium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dopamine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dopamine uptake IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serotonin uptake IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Major facilitator superfamily (MFS) profile domain-containing protein
    NP_001024936.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5705690..5710625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029765.5 → NP_001024936.1  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024936.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GNP0
      Conserved Domains (1) summary
      cd17384
      Location:18 → 499
      MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version

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