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Links from GEO Profiles

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    Map1b microtubule-associated protein 1B [ Mus musculus (house mouse) ]

    Gene ID: 17755, updated on 4-Jan-2025

    Summary

    Official Symbol
    Map1bprovided by MGI
    Official Full Name
    microtubule-associated protein 1Bprovided by MGI
    Primary source
    MGI:MGI:1306778
    See related
    Ensembl:ENSMUSG00000052727 AllianceGenome:MGI:1306778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LC1; MAP5; Mtap5; Mtap-5; Mtap1b; A230055D22
    Summary
    Predicted to enable actin binding activity; microtubule binding activity; and phospholipid binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including establishment of monopolar cell polarity; mitochondrion transport along microtubule; and neuron projection development. Located in several cellular components, including neuronal cell body; photoreceptor outer segment; and postsynaptic density. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; genitourinary system; intestine smooth muscle circular layer; nose; and trigeminal nerve. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 83 and periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in whole brain E14.5 (RPKM 66.4), CNS E18 (RPKM 61.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Map1b in Genome Data Viewer
    Location:
    13 D1; 13 52.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (99557972..99653110, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (99421464..99516602, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35456 Neighboring gene STARR-positive B cell enhancer mm9_chr13:100123104-100123405 Neighboring gene pentatricopeptide repeat domain 2 Neighboring gene mitochondrial ribosomal protein S27 Neighboring gene RIKEN cDNA 6430562O15 gene Neighboring gene STARR-seq mESC enhancer starr_35459 Neighboring gene predicted gene, 26559 Neighboring gene STARR-seq mESC enhancer starr_35465 Neighboring gene STARR-seq mESC enhancer starr_35466 Neighboring gene predicted gene, 24471

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC169657, MGC169658

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding  
    enables actin binding  
    enables actin binding  
    enables cytoskeletal regulatory protein binding PubMed 
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule binding  
    enables phospholipid binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension PubMed 
    involved_in axonogenesis  
    acts_upstream_of_or_within axonogenesis PubMed 
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to peptide hormone stimulus  
    involved_in dendrite development  
    acts_upstream_of_or_within dendrite development PubMed 
    involved_in developmental maturation  
    acts_upstream_of_or_within establishment of monopolar cell polarity PubMed 
    involved_in induction of synaptic plasticity by chemical substance  
    acts_upstream_of intracellular transport PubMed 
    acts_upstream_of_or_within microtubule bundle formation PubMed 
    involved_in microtubule bundle formation  
    involved_in microtubule cytoskeleton organization  
    acts_upstream_of_or_within microtubule-based process PubMed 
    acts_upstream_of_or_within mitochondrion transport along microtubule PubMed 
    acts_upstream_of_or_within negative regulation of intracellular transport PubMed 
    involved_in negative regulation of microtubule depolymerization  
    involved_in negative regulation of microtubule depolymerization  
    involved_in neuron projection development  
    involved_in neuron projection development  
    involved_in odontoblast differentiation  
    involved_in peripheral nervous system axon regeneration  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of axon extension  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron differentiation  
    involved_in regulation of microtubule depolymerization  
    involved_in regulation of postsynapse assembly PubMed 
    involved_in regulation of postsynapse assembly PubMed 
    involved_in response to carbohydrate  
    involved_in response to estradiol  
    involved_in response to insecticide  
    involved_in response to mechanical stimulus  
    involved_in response to vitamin A  
    involved_in response to xenobiotic stimulus  
    involved_in synapse assembly  
    Items 1 - 25 of 39
    Items 1 - 20 of 40
    Component Evidence Code Pubs
    located_in apical dendrite  
    located_in apical dendrite  
    located_in axon  
    located_in basal dendrite  
    located_in basal dendrite  
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    is_active_in dendrite  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in dendritic spine  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in growth cone  
    located_in growth cone  
    located_in hippocampal mossy fiber  
    located_in hippocampal mossy fiber  
    is_active_in microtubule  
    located_in microtubule  
    located_in microtubule  
    part_of microtubule associated complex  
    part_of microtubule associated complex  
    part_of microtubule associated complex PubMed 
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in perikaryon  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in photoreceptor outer segment PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse PubMed 
    located_in postsynaptic density PubMed 
    located_in somatodendritic compartment  
    is_active_in synapse  
    located_in varicosity  
    located_in varicosity  
    Items 1 - 20 of 40

    General protein information

    Preferred Names
    microtubule-associated protein 1B
    Names
    MAP-1B
    MAP1(X)
    MAP1.2
    Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X))
    microtubule-associated protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008634.2 → NP_032660.2  microtubule-associated protein 1B

      See identical proteins and their annotated locations for NP_032660.2

      Status: VALIDATED

      Source sequence(s)
      AC170188, AK148870, BC037105, BY003859
      Consensus CDS
      CCDS26723.1
      UniProtKB/Swiss-Prot
      E9QM11, P14873
      UniProtKB/TrEMBL
      B2RQQ5
      Related
      ENSMUSP00000068374.5, ENSMUST00000064762.6
      Conserved Domains (1) summary
      pfam05109
      Location:1265 → 1630
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      99557972..99653110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517548.3 → XP_006517611.1  microtubule-associated protein 1B isoform X1

      UniProtKB/TrEMBL
      B2RQQ5
      Conserved Domains (1) summary
      pfam03154
      Location:1258 → 1701
      Atrophin-1; Atrophin-1 family
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